Tilly
Senior Member (Voting Rights)
The interest in mast cells in arthritis really goes back to a paper by Adrian Crisp around 1994. But nothing has ever indicated that mast cells have a special involvement in human joint disease - it is just that they are present in all connective tissues in bucketloads and are always caught up in inflammation. If you remove them from mice the inflammation is likely to be less but that tells us nothing about human disease.
I think you will find this interesting https://www.sciencealert.com/hidden...ound-in-bones-is-totally-crazy-scientists-say