The putative glymphatic signature of chronic fatigue syndrome: A new view on the disease pathogenesis and therapy, 2018, Wostyn et al

[Alvin]

Haven't we all!

Why don't y'all PM me and we can set up a time to discuss? If you're comfortable doing so.

Will do. I have several other things i was asked to PM you about but have put off for a while

 

[JaimeS]

Yeah, whoever's interested is welcome to PM me to join in for first discussions. Let's set it for beginning of Sept or something along those lines, so that we can have time to gather folk.

 

[Skycloud]

@JaimeS @Alvin New thread?

I think it's a great idea and I hope you get a good level of interest

 

[JaimeS]

@JaimeS @Alvin New thread?

I think it's a great idea and I hope you get a good level of interest

Good idea.

 

[Andy]

Merged thread

Retinal nerve fiber layer thinning in chronic fatigue syndrome as a possible ocular biomarker of underlying glymphatic system dysfunction,2019, Wostyn

Dear editor
In a recent article published in Medical Hypotheses, my colleague and I speculated that glymphatic dysfunction, causing toxic build up within the central nervous system, may be responsible for at least some cases of chronic fatigue syndrome (CFS) [1]. We further postulated that cerebrospinal fluid diversion such as lumboperitoneal shunting may be beneficial to this subgroup of patients by restoring glymphatic transport and waste removal from the brain. In this context, it would be helpful to have a predictive biomarker that can identify CFS patients who are good candidates for this specific treatment. For reasons discussed below, I believe that retinal nerve fiber layer (RNFL) thinning may be a sign of underlying glymphatic system dysfunction in neurodegenerative diseases that result from protein toxicity.

Open access, https://www.sciencedirect.com/science/article/pii/S0306987719310667

 

[Trish]

Interesting:

Declaration of Competing Interest
Dr. Peter Wostyn is the inventor of a pending patent application pertaining to chronic fatigue syndrome treatment using cerebrospinal fluid diversion procedures, and pertaining retinal nerve fiber layer thinning as a biomarker of underlying glymphatic system dysfunction.

 

[Barry]

Interesting:

Declaration of Competing Interest
Dr. Peter Wostyn is the inventor of a pending patent application pertaining to chronic fatigue syndrome treatment using cerebrospinal fluid diversion procedures, and pertaining retinal nerve fiber layer thinning as a biomarker of underlying glymphatic system dysfunction.

Definitely is interesting, though I do worry when a scientist seeks to patent something like this, presumably for their own future financial gain, rather than allowing their discovery be made generally available for the benefit of all.

 

[Madbeggar]

I went down a rabbit hole of research on this guy and related studies. I eventually ended up at the 2022 paper, Effects of Sound Interventions on the Permeability of the Blood–Brain Barrier and Meningeal Lymphatic Clearance, where they report this good news for headbangers:

"Another study exposed mice to Scorpions’ “Still Loving You” at 100 dB [20]. One hour after music exposure, BBB permeability increased 17.3-fold. Importantly, however, this permeability increase was induced only at 90-dB and 100-dB sound levels. The experimental group exposed to music at 70 dB experienced the same rise in BBB permeability as controls."

 

[Michelle]

"Another study exposed mice to Scorpions’ “Still Loving You” at 100 dB [20]. One hour after music exposure, BBB permeability increased 17.3-fold. Importantly, however, this permeability increase was induced only at 90-dB and 100-dB sound levels. The experimental group exposed to music at 70 dB experienced the same rise in BBB permeability as controls."

Well...whenever I'm really badly off, I always crave Enya. Or certain Tibetan Singing Bowls. I've never really known what to make of that. Though I have sometimes wondered if certain frequencies have some sort of effect on whatever mechanism of action is going on in a crash.

Can't say the Scorpion song would be tolerable during a crash though.

 

[Wyva]

Can't say the Scorpion song would be tolerable during a crash though.

I was a huge metal fan in my younger days, attended tons of concerts and festivals. I didn't listen to the really melodic bands like Iron Maiden etc but to bands from Nordic countries with a more abrasive sound than that. You can imagine how much I can listen to that now. I mean I can but I really have to find the perfect time for it...

 

[CRG]

I was a huge metal fan in my younger days, attended tons of concerts and festivals. I didn't listen to the really melodic bands like Iron Maiden etc but to bands from Nordic countries with a more abrasive sound than that. You can imagine how much I can listen to that now. I mean I can but I really have to find the perfect time for it...

Not available in my hippy youth - but still there are some days now when nothing else but Combichrist will do .

 

[Madbeggar]

Can't say the Scorpion song would be tolerable during a crash though.

Well, no - not at 70dB, Michelle.
But have you tried 100 dB?
You've got to get over that 90 dB hump to really get the brain juice flowing.