The effect of evening primrose oil on fatigue and quality of life in patients with multiple sclerosis

Early on Efamol was really recommended. I think Dr. Peter Behan had some success with this - could just be my ME memory though. I've tried it off and on. Didn't notice anything. Someone I knew with Fibro tried it, and they said it made them feel very angry.
 
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Jaybee00 said:
Looks like @alex3619 is not a fan
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Evening primrose oil can help for some at low doses for short periods. It can also harm. Its a tricky thing to get the dose right over time. I spent years trying to optimise it, but gave up, back in the mid 90s. It will increase cell deformability, but has many hormonal effects too, including inflammatory. Omega 3 fats and monounsaturated fats will also have an impact on cell membrane deformability.

These days I am more in favour of monounsaturated fats, due to them not being used to make inflammatory hormones, but its tricky if you are salicylate intolerant as most sources are high in salicylates, and most of the rest are moderate. Omega-3 fats in moderation are another choice, but I am still careful. Contrary to popular science they are inflammatory for the most part.

The reason they appear anti-inflammatory is that the body will use them over omega-6s, but the 6s are much more inflammatory. There are also anti-inflammatory pathways, but we don't have a means to fine tune them. These polyunsaturated fats lead to dozens if not hundreds of hormones.

Research on this was done in Australia in the early 90s, but most was not published. I was one of the guinea pigs, and pioneered very high dose omega 3.
 
thanks.

Is a lot or a little? (from above study)

The experimental group: Patients were asked to take 1 g oral capsule containing EPO every 12 hours for 3 months in addition to the standard treatment for their disease.
 
DokaGirl said:
Early on Efamol was really recommended. I think Dr. Peter Behan had some success with this - could just be my ME memory though. I've tried it off and on. Didn't notice anything. Someone I knew with Fibro tried it, and they said it made them feel very angry.
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Very interesting! I had a friend with FM who also told me the same thing! She suffered from depression.
 
Mij said:
The ME doctor I saw in 1992 recommended Efamol for his patients, so I took it for over a year with no positive or negative effects.
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When I was first diagnosed with ME/CFS a ND recommended that I take EPO, however, I never noticed any difference good or bad.
 
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