The effect of Delphinium denudatum (Jadwar) on fatigue: A randomized double blind placebo-controlled clinical trial, 2019, Daneshfard et al

Andy

Andy

Retired committee member
I know that fatigue≠ME/CFS but maybe the study might be of some use, possibly (I doubt it but you never know).
Highlights

• Fatigue, whether acute or chronic, is a common challenging problem in modern societies.
• Various herbal medicines have been used for fatigue treatment.
• Delphinium denudatum (Jadwar) showed potentials of a tonic agent with anti-fatigue effect.

Abstract

Objectives
Fatigue is a common problem in modern-day life. The aim of this study was to evaluate the effect of Delphinium denudatum (Jadwar) on fatigue.

Methods
This study was a randomized double-blind placebo-controlled clinical trial between healthy normal university students. In each group, participants were given one capsule of either WEACURE® (containing 500 mg of Jadwar root powder) or placebo for 15 consecutive days. Multidimensional Fatigue Inventory (MFI) questionnaire was used before and after the intervention to evaluate different aspects of fatigue.

Results
A total number of 64 participants completed the study. Data analysis showed decrease in the scores of all five domains of fatigue in Jadwar group (13.31 ± 3.05–7.75 ± 2.66, 12.31 ± 3.55–7.63 ± 2.62, 12.22 ± 4.26–6.97 ± 2.06, 11.56 ± 4.21 to 7.28 ± 2.37, 12.91 ± 3.09–7.34 ± 2.13 in general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue domains, respectively) which was statistically significant (P value<0.0001). This situation was significantly superior to the placebo group. Prescribed dosage of WEACURE® capsule was well tolerated.

Conclusion
As a complementary tonic agent, Jadwar have a potential to reduce fatigue in normal population. However, objective evaluation of its anti-fatigue effect should be further evaluated.
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Paywall, https://www.sciencedirect.com/science/article/abs/pii/S0965229919301542
Sci hub, https://sci-hub.se/10.1016/j.ctim.2019.05.027
 
Jonathan Edwards said:
So why did the placebo group get a little worse on all measures? Not much of a placebo it seems.
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The normal effects of student life?
I suspect a lot of students get more tired as term proceeds as they burn the candle at both ends with a mix of social activities and study deadlines.
 
We do not know if our fatigue is a protective response against a problem with our biology the way it is in things like flu. If it is, stimulants could be dangerous, think of racing cyclists who die after taking cocaine to keep them going.

If it is a switch that is stuck in the on position they could be good for us. Time some research found out which it is.
 
Chronic Fatigue Syndrome (CFS), also known as myalgic encephalomyelitis, is a long-term challenging disorder with fluctuating symptoms including prolonged unexplained fatigue, musculoskeletal pain, disturbed memory and cognition, headache, and poor sleep. 2,3 This relatively common condition is an inevitable consequence of modern-day life, affecting all races and socioeconomic classes. CFS prevalence rate varies 1.5-3% in the general population. 3,4 It is estimated that 836,000 to 2.5 million Americans have had CFS in 2015, most of which remained undiagnosed. 5 Depression and anxiety disorders have a high prevalence rate amongst CFS patients, which in turn increases the disease burden. 6
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[My bold]

Cobblers!
Although there is no treatment for CFS, cognitive behavioral therapy and graded exercise have shown to be effective.
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Cobblers again!
 
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