The Effect of Curcumin in Patients with CFS/ME Disparate Responses in Different Disease Severities, 2019, van Campen & Visser

Dolphin

Senior Member (Voting Rights)
Free full text:
http://edelweisspublications.com/ed...c-encephalomyelitis-2638-8235-pvpe-19-112.pdf

https://doi.org/10.33805/2638-8235.112
Volume 2 Issue 1 | PDF 112 | Pages 6 Pharmacovigilance and
Pharmacoepidemiology

Citation: Campen CMCV and Visser FC. The effect of curcumin in patients with chronic fatigue
syndrome/myalgic encephalomyelitis: disparate responses in different disease severities (2019) Pharmacovigil and Pharmacoepi 2: 22-27. 22
Research Article ISSN: 2638-8235

The Effect of Curcumin in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Disparate Responses in Different Disease Severities

C(Linda) MC van Campen*and Frans C Visser

Affiliation: Department of Cardiology, Stichting Cardiozorg, Hoofddorp, Netherlands

*Corresponding author: C (Linda) MC van Campen, Department of Cardiology, Stichting Cardiozorg, Hoofddorp, Netherlands, E-mail: info@stichtingcardiozorg.nl

Citation: Campen CMCV and Visser FC. The effect of curcumin in patients with chronic fatigue syndrome/myalgic encephalomyelitis: disparate responses in different disease severities (2019) Pharmacovigil and Pharmacoepi 2: 22-27.

Received: Oct 31, 2019
Accepted: Nov 13, 2019
Published: Nov 19, 2019

Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is a chronic and often disabling disease. Although the exact pathophysiological mechanism of ME/CFS is unknown, immunological abnormalities may play an important role. Curcumin is an herb with powerful anti-oxidative and anti-inflammatory properties.

Therefore, we hypothesized that curcumin would have favorable effects on symptomatology in ME/CFS patients.

In an open trial among 65 ME/CFS participants, 6 stopped the use of curcumin because of side effects and 8 did not complete the end of study questionnaire.

Before and 8 weeks after the use of curcumin complexed with phosphatidyl choline-, 500 mg bid, participants completed the CDC inventory for assessment of Chronic Fatigue Syndrome.

The CDC questions (n=19) were scored and divided into 2 parts: the first being specific for CFS complaints (n=9), the second being scores of less specific symptoms (n=10); denoted as CDC other score.

Results showed that 8 weeks of curcumin significantly decreased the CDC CFS-related symptom scores and CDC other scores, especially in patients with mild disease.

Conclusion:

in this open-labeled study 8 week curcumin use in a phosphatidyl choline complex reduced ME/CFS symptomatology, especially in patients with mild disease severity.

Keywords: Curcumin, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Disease severity, CDC score, Fukuda score, R and 36 questionnaire.

Abbreviations: TNF-Tumor Necrosis Factor, ME/CFS-Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, CDC-Center for Disease Control and Prevention, PROM-Patient Reported Outcome Measure, COPD-Chronic Obstructive Pulmonary Disease.
 
The only good thing about it is it looks as though they showed curcumin is pretty useless anyway as an ME treatment.

As a matter of curiosity, how can we tell it's a predatory journal? I did notice it's fairly new, uses long words in the title, and the paper was published within a couple of weeks of receipt - suggesting lack of peer review. That all suggested to me it's not a serious journal.
 
Didn't Jarred Younger complete a study looking into various botanicals that could target 'brain inflammation'? Curcumin was listed as one of them. I think they are going to publish it soon.
 
The only good thing about it is it looks as though they showed curcumin is pretty useless anyway as an ME treatment.

As a matter of curiosity, how can we tell it's a predatory journal? I did notice it's fairly new, uses long words in the title, and the paper was published within a couple of weeks of receipt - suggesting lack of peer review. That all suggested to me it's not a serious journal.
Curcumin is not useless as a treatment. Some people, such as myself, it makes a huge difference to. Others, it makes no difference. I guess there are differences in the things that are happening inside our bodies.
 
Curcumin is not useless as a treatment. Some people, such as myself, it makes a huge difference to. Others, it makes no difference. I guess there are differences in the things that are happening inside our bodies.
I should have said the trial showed very little effect, and nothing significant for the moderate and severe sufferers.

Our bodies are indeed very puzzling. I'm glad it helps you, Sarah.
 
I used to drink organic matcha green tea because 'they' claimed it was a powerful antioxidant and had anti-inflammatory properties. Then I read a study that said we would have to drink 1/3 cup (of powder) daily in order to get any benefits.
That's a lot of tea!


A friend of mine whose adult son is autistic had seizures from drinking matcha green tea.
 
So it kind of looks like the CDC inventory for assessment of Chronic Fatigue Syndrome is a lousy assessment. Who knew that a crude tool of limited reliability could be, well, unreliable?

The worst thing about this obsession over lousy questionnaires is that modern science was essentially made on the need for precision in measurement. When science really got its wings is when it started to be possible to measure temperatures, masses and other properties of matter with high precision and accuracy. Before then "science" was pretty much like this right here: crude measurements, speculation and opinion anchoring.

Stop wasting time with whole number measurements when you need 8 digits precision. Speculation is entirely wasted trying to make sense of measurements that do not even give the same outcomes out of the same initial conditions.

Though I do appreciate the language use, of an open label trial. This is language trials like PACE should have used had they been honest. Except it would obviously not have had the influence needed for the con game.
 
Back
Top Bottom