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http://edelweisspublications.com/ed...c-encephalomyelitis-2638-8235-pvpe-19-112.pdf
http://edelweisspublications.com/ed...c-encephalomyelitis-2638-8235-pvpe-19-112.pdf
https://doi.org/10.33805/2638-8235.112
Volume 2 Issue 1 | PDF 112 | Pages 6 Pharmacovigilance and
Pharmacoepidemiology
Citation: Campen CMCV and Visser FC. The effect of curcumin in patients with chronic fatigue
syndrome/myalgic encephalomyelitis: disparate responses in different disease severities (2019) Pharmacovigil and Pharmacoepi 2: 22-27. 22
Research Article ISSN: 2638-8235
The Effect of Curcumin in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Disparate Responses in Different Disease Severities
C(Linda) MC van Campen*and Frans C Visser
Affiliation: Department of Cardiology, Stichting Cardiozorg, Hoofddorp, Netherlands
*Corresponding author: C (Linda) MC van Campen, Department of Cardiology, Stichting Cardiozorg, Hoofddorp, Netherlands, E-mail: info@stichtingcardiozorg.nl
Citation: Campen CMCV and Visser FC. The effect of curcumin in patients with chronic fatigue syndrome/myalgic encephalomyelitis: disparate responses in different disease severities (2019) Pharmacovigil and Pharmacoepi 2: 22-27.
Received: Oct 31, 2019
Accepted: Nov 13, 2019
Published: Nov 19, 2019
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is a chronic and often disabling disease. Although the exact pathophysiological mechanism of ME/CFS is unknown, immunological abnormalities may play an important role. Curcumin is an herb with powerful anti-oxidative and anti-inflammatory properties.
Therefore, we hypothesized that curcumin would have favorable effects on symptomatology in ME/CFS patients.
In an open trial among 65 ME/CFS participants, 6 stopped the use of curcumin because of side effects and 8 did not complete the end of study questionnaire.
Before and 8 weeks after the use of curcumin complexed with phosphatidyl choline-, 500 mg bid, participants completed the CDC inventory for assessment of Chronic Fatigue Syndrome.
The CDC questions (n=19) were scored and divided into 2 parts: the first being specific for CFS complaints (n=9), the second being scores of less specific symptoms (n=10); denoted as CDC other score.
Results showed that 8 weeks of curcumin significantly decreased the CDC CFS-related symptom scores and CDC other scores, especially in patients with mild disease.
Conclusion:
in this open-labeled study 8 week curcumin use in a phosphatidyl choline complex reduced ME/CFS symptomatology, especially in patients with mild disease severity.
Keywords: Curcumin, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Disease severity, CDC score, Fukuda score, R and 36 questionnaire.
Abbreviations: TNF-Tumor Necrosis Factor, ME/CFS-Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, CDC-Center for Disease Control and Prevention, PROM-Patient Reported Outcome Measure, COPD-Chronic Obstructive Pulmonary Disease.