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Shared Microglial Mechanisms Underpinning Depression and Fatigue and Their Comorbidities - (2019) Filho, Macedo,Freitas de Lucena,Maes

Discussion in 'BioMedical ME/CFS Research' started by Sly Saint, Feb 5, 2019.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    This version is not peer-reviewed

    https://www.preprints.org/manuscript/201902.0029/v1

    https://www.google.com/url?sa=t&rct.../v1/download&usg=AOvVaw3-atyrhyiH7f_-_3RgcGNc
     
    MEMarge, Inara, Trish and 2 others like this.
  2. Andy

    Andy Committee Member & Outreach

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  3. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    Lack of specificity of scientific findings is not a strength, it is a weakness.
     
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  4. Mithriel

    Mithriel Senior Member (Voting Rights)

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    Is there any evidence that true depression exists for people with ME more than the rest of the population? I do not mean the frustration, sadness and grieving that is a rational response to our situation. That suicide is so common is not a sign of depression (where people cannot see the hope in the world) but is a choice to end a situation where there is little chance of it improving. (I am not playing down the suffering of depression, it is an awful illness, just saying it is different)

    The link with ME was originally made because the depression questionnaires included sections on physical things. I remember one academic with ME who took out all the questions that indicated physical ill health and the number of people with ME who also had depression dropped to zero whereas if they included things like fatigue the number shot up to 100%

    Has the evidence base improved since then?
     
  5. Medfeb

    Medfeb Senior Member (Voting Rights)

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    I'd have to dig up the source but I've read that the rate of depression is not greater in ME than in other chronic diseases.
     
  6. Seven

    Seven Senior Member (Voting Rights)

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    I forgot if it was a protein or what in the profile but I remember reading what was very low on depresiĆ³n was high in ME or viceversa. Protein or a neurotransmitter. But I remember thinking well there goes the theory you can have both.
     
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