Shared Microglial Mechanisms Underpinning Depression and Fatigue and Their Comorbidities - (2019) Filho, Macedo,Freitas de Lucena,Maes

This version is not peer-reviewed

https://www.preprints.org/manuscript/201902.0029/v1

https://www.google.com/url?sa=t&rct.../v1/download&usg=AOvVaw3-atyrhyiH7f_-_3RgcGNc

 

Paywalled at https://www.sciencedirect.com/science/article/pii/S0166432819302037

Sci Hub, https://sci-hub.se/10.1016/j.bbr.2019.111975

 

Lack of specificity of scientific findings is not a strength, it is a weakness.

 

Is there any evidence that true depression exists for people with ME more than the rest of the population? I do not mean the frustration, sadness and grieving that is a rational response to our situation. That suicide is so common is not a sign of depression (where people cannot see the hope in the world) but is a choice to end a situation where there is little chance of it improving. (I am not playing down the suffering of depression, it is an awful illness, just saying it is different)

The link with ME was originally made because the depression questionnaires included sections on physical things. I remember one academic with ME who took out all the questions that indicated physical ill health and the number of people with ME who also had depression dropped to zero whereas if they included things like fatigue the number shot up to 100%

Has the evidence base improved since then?

 

I'd have to dig up the source but I've read that the rate of depression is not greater in ME than in other chronic diseases.

 

I forgot if it was a protein or what in the profile but I remember reading what was very low on depresión was high in ME or viceversa. Protein or a neurotransmitter. But I remember thinking well there goes the theory you can have both.