Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder, 2020, Sakurai et al

Andy · Feb 7, 2020

Previous reports have shown that during chronic inflammation, the tryptophan (TRP)-kynurenine (KYN) pathway plays a pivotal role in the onset of depression. The aim of this study was to investigate the characteristics of the serum TRP-KYN pathway metabolite profile in high-risk subjects of major depressive disorder (HRMDD) defined by depression scores.

The concentrations of TRP-KYN pathway metabolites {TRP, KYN, 3-hydroxyanthranilic acid (3HAA), 3-hydroxykynurenine (3HK), kynurenic acid (KYNA) and anthranilic acid (AA)} were assessed in serum from HRMDD, chronic pain disorder patients and healthy controls. In serum from HRMDD, elevated levels of AA and decreased levels of TRP were observed, but the levels of other metabolites were not changed. Furthermore, the change in the AA2nd/AA1st ratio in subjects who progressed from a health. y state to a depressive state was correlated with an increase in the CES-D score. The level of IL-1 receptor antagonist (IL-1RA) was negatively correlated with that of AA.

Interestingly, we confirmed AA as a possible biomarker for depression-related symptoms, since the metabolite profiles in the chronic pain disorder group and chronic unpredictable mild stress model mice were similar to those in the HRMDD. These results suggest that AA may be an effective marker for HRMDD.
Click to expand...

Open access, https://www.nature.com/articles/s41598-020-58806-w

mariovitali · Feb 8, 2020

I wanted to quote the following text, paying attention to Quinolinic Acid :

The KYN pathway produces various metabolites, such as KYN, 3-hydroxykynurenine (3HK), anthranilic acid (AA), kynurenic acid (KYNA), 3-hydroxyanthranilic acid (3HAA) and quinolinic acid (QUIN). These metabolites have been reported to have various physiological activities. For example, 3HK and QUIN are known to cause neurotoxicity due to their active oxygen production and their agonistic activity via NMDA-type glutamate receptors.
Click to expand...

According to Machine Learning, Quinolinic acid should be further investigated and is hypothesised to be one of the factors responsible for the vicious cycle of ME/CFS

Log in or Sign up

Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder, 2020, Sakurai et al

Andy Committee Member

mariovitali Senior Member (Voting Rights)

Share This Page

Log in or Sign up

Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder, 2020, Sakurai et al

Andy Committee Member

mariovitali Senior Member (Voting Rights)

Share This Page

Useful Searches