Ron Davis: Grant award: Molecular and single-cell immunology in ME/CFS

Great to hear that money are comming. I think with The Pineapple Fund donation, OMF, NIH and many donors - Stanford research team will not be far away form the budget 10 mil. USD a year. I think this can really move the research on Stanford. It would be great to have such a team with that budget also in UK. What to do about it?
I followed some crowdfunding campaigns for research projects in UK (IiME,...) but they were able to get only 100 000 a year, i never understood why so little.
 
tuha said:
Great to hear that money are comming. I think with The Pineapple Fund donation, OMF, NIH and many donors - Stanford research team will not be far away form the budget 10 mil. USD a year. I think this can really move the research on Stanford. It would be great to have such a team with that budget also in UK. What to do about it?
I followed some crowdfunding campaigns for research projects in UK (IiME,...) but they were able to get only 100 000 a year, i never understood why so little.
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Thats one year....Pine won't be coming in again, they are nowhere near 10 million per year really...
 
JaimeS said:
Ongoing, so far as I'm aware. Beyond saying that the SGTC team is still working on it -- and because they're still working on it -- I shouldn't say anything else. :thumbup:
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I did wonder if this was some form of autoantibody stuck on translocator membranes as postulated by Prof Behan in 1980s .

There are a lot of interesting studies which got sidetracked after BPS hijacked agenda - which are being rediscovered- eg sticky blood. These are not new phenomena, just forgotten.

It would be worthwhile trawling past research in pertinent areas- given the technology and processes now available who knows where thus may lead ?
 
Happened to be reading this
Genetic risk factors of ME/CFS: a critical review
Joshua J Dibble, Simon J McGrath, Chris P Ponting
And noticed this reference:
"The MHC locus and genetic susceptibility to autoimmune and infectious diseases"
29.Matzaraki, V., Kumar, V., Wijmenga, C. and Zhernakova, A. (2017) The MHC locus and genetic susceptibility to autoimmune and infectious diseases Genome Biol.

So the Stanford study may test whether ME/CFS has a strong MHC/HLA "autoimmune and infectious diseases" link?
 
The paper said —

we have shown that WASF3, induced by ER stress, disrupts the formation of respiratory supercomplexes and reduces mitochondrial oxygen consumption, providing a molecular explanation for the energy deficiency symptoms of exercise intolerance and postexertional malaise in a patient with chronic fatigue
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Although the reason for the increased ER stress is unclear, its specific reduction in the patient’s cells by salubrinal implicates the activation of eIF2α by dysregulated phosphatase PP1 as has been reported, for example, by viral infection
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So I don't think it would be WASF3 itself, but perhaps instead it's something impairing the ER stress response (via eIF2a) that then induces increased intracellular WASF3.

(Maybe the upstream mechanism involves one or more microRNAs or circRNAs??)
 
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