Ron Davis: Grant award: Molecular and single-cell immunology in ME/CFS

Ron Davis has been awarded several million dollars by the US National Institute of Allergy and Infectious Diseases to "uncover the immunological basis of ME" by examining T cell activity and related genetic factors, and by hunting for pathogens. The project start date is this month, and the end date is May 2023.

https://projectreporter.nih.gov/project_info_description.cfm?aid=9577948&icde=40034644

Edit: typo
Edit2: updated funding amount

 

The entire funding is for 5 year, but couldn't we expect more than one paper out of this research...so that some information is published before the end of five years?

 

Judging from the description, this is the Mark Davis T cell receptor stuff.

 

Finally, they have given him money. I wonder does he get all the money upfront or a set amount each year. It's not alot over 5 years but a start

 

Someone clarified to me that it is $775,509 each year for 5 years.

 

Are u saying .75 million per year??? Where is this info coming from, I don't see any announcements on their Facebook page. If it's .75 million per year that's brilliant

 

Yes, the grant shows $775,000 for FY 2018-2019, but the project end date is 2023. So it's expected to refund each year for five years.

 

That is what Cort is reporting on Health Rising.

 

Yes, I noticed that between "Autoimmunity" and "Autoreactivity" they wedged in "Automobile Driving."


[Fantastic news BTW!]

 

The presence of nonsense terms suggests they are automatically generated with an imperfect algorithm.

 

Really great news! And we couldn't have a better team working on this.

Like the first para of the summary too:

"PROJECT SUMMARY Myalgic encephalomyelitis, also known as chronic fatigue syndrome (ME/CFS), is a complex, debilitating disease that has baffled researchers for decades. Its inaccurate yet frequent dismissal as a psychosomatic condition and lack of recognition by many in the biomedical community have greatly hindered research; as a result, very little is known about its cause(s), and no biological diagnosis or approved treatments are available. Recent developments have more clearly defined this mysterious illness, and it is now clear that it afflicts up to 2.5 million in the United States and millions more worldwide."

And it would be so good if this research could also help GWS, lyme etc

 

Great news for IOM and us

More here

https://www.healthrising.org/blog/2018/06/25/davis-nih-grant-chronic-fatigue-syndrome/

Not sure if Corts funding figures are accurate

Edit IOM are announcing it as multi-million dollar funding, so suggests yearly figures?

 

Confirmation that the funding is in the multi-millions of dollars from OMF:
https://twitter.com/user/status/1011345300253003779

 

How does the HLA locus fit into the metabolic trap hypothesis ?

I think Ron said at LiME 2017 that HLA sequence showed interesting results in severely ill patients

 

It is simply awesome news, it looks like a study that seeks to answer a lot of big questions and the money is coming from the NIH immediately , rather than us trying to slowly crowdfund for this as well as lots of other things as used to happen.

 

This is huge!

Stoked to see its about t-cells, i had some double positive expression of something on mine which some hospital found out a bit randomly when testing for other things. They didnt know what it meant

 

I think this shows that Chris Ponting's replication attempt on the earlier work by Mark Davis is even more timely now - should Ron find anything with this study, then we'll be able to have a higher confidence in it if the replication is successful.

Have we ever had a situation, at least in recent ME history, where a line of investigation is ongoing and replication efforts are taking place concurrently, in the way that we have here?