1. Guest, the two part 'News in Brief' for the week beginning 5th April 2021 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study, 2006, Hickie, Lloyd et al

Discussion in 'BioMedical ME/CFS Research' started by Dolphin, Dec 7, 2017.

  1. Dolphin

    Dolphin Senior Member (Voting Rights)

    Messages:
    2,916
    Likes Received:
    16,201
    This thread has been split from here.

    CDC-funded study:

    BMJ. 2006 Sep 16;333(7568):575. Epub 2006 Sep 1.
    Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study.
    Hickie I1, Davenport T, Wakefield D, Vollmer-Conna U, Cameron B, Vernon SD, Reeves WC, Lloyd A; Dubbo Infection Outcomes Study Group.
    Author information

    Abstract
    OBJECTIVE:
    To delineate the risk factors, symptom patterns, and longitudinal course of prolonged illnesses after a variety of acute infections.

    DESIGN:
    Prospective cohort study following patients from the time of acute infection with Epstein-Barr virus (glandular fever), Coxiella burnetii (Q fever), or Ross River virus (epidemic polyarthritis).

    SETTING:
    The region surrounding the township of Dubbo in rural Australia, encompassing a 200 km geographical radius and 104,400 residents.

    PARTICIPANTS:
    253 patients enrolled and followed at regular intervals over 12 months by self report, structured interview, and clinical assessment.

    OUTCOME MEASURES:
    Detailed medical, psychiatric, and laboratory evaluations at six months to apply diagnostic criteria for chronic fatigue syndrome. Premorbid and intercurrent illness characteristics recorded to define risk factors for chronic fatigue syndrome. Self reported illness phenotypes compared between infective groups.

    RESULTS:
    Prolonged illness characterised by disabling fatigue, musculoskeletal pain, neurocognitive difficulties, and mood disturbance was evident in 29 (12%) of 253 participants at six months, of whom 28 (11%) met the diagnostic criteria for chronic fatigue syndrome. This post-infective fatigue syndrome phenotype was stereotyped and occurred at a similar incidence after each infection. The syndrome was predicted largely by the severity of the acute illness rather than by demographic, psychological, or microbiological factors.

    CONCLUSIONS:
    A relatively uniform post-infective fatigue syndrome persists in a significant minority of patients for six months or more after clinical infection with several different viral and non-viral micro-organisms. Post-infective fatigue syndrome is a valid illness model for investigating one pathophysiological pathway to chronic fatigue syndrome.

    PMID:

    16950834

    PMCID:

    PMC1569956

    DOI:

    10.1136/bmj.38933.585764.AE
    [Indexed for MEDLINE]
     
    Last edited by a moderator: Nov 4, 2019
    Sean, Trish, Forbin and 6 others like this.
  2. Hutan

    Hutan Moderator Staff Member

    Messages:
    13,055
    Likes Received:
    53,667
    Location:
    New Zealand
    An oldie but a goodie, an important post-viral fatigue/CFS prospective study.
     
    Sean, Trish, Forbin and 2 others like this.

Share This Page