PET/SPECT/MRI/fMRI Studies in the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2020, Watanabe

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https://link.springer.com/chapter/10.1007/978-3-030-57231-0_32

PET/SPECT/MRI/fMRI Studies in the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, debilitating disorder with a wide spectrum of symptoms, including fatigue, pain, depression and neurocognitive deterioration. Over 17 million people around the world have ME/CFS, predominantly women with peak onset at 30–50 years. Given the wide spectrum of symptoms and unclear etiology, specific biomarkers for diagnosis and stratification of ME/CFS are lacking. Here the results from PET/SPECT/MRI/fMRI studies are reviewed to understand the pathophysiology and to develop therapies of this severe syndrome.

Keywords
  • Myalgic encephalomyelytis/chronic fatigue syndrome
  • Brain morphometry
  • Connectivity
  • Regional cerebral blood flow
  • Glucose utilization rate
  • Serotonergic deterioration
  • Neuroinflammation
  • Repair energy loss
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