pet scan

An open-label, clinical feasibility study of the efficacy of Remdesivir for Long-COVID BACKGROUND Long COVID (LC) affects around two million people in the UK and over 65 million people globally. Antiviral medications have shown positive effects in reducing the risk of progression to severe...

Association between post-COVID-19 neuropsychiatric symptoms and persistent glial activation in the limbic system: a TSPO PET study Background A subset of individuals experience prolonged neurological and psychiatric symptoms following SARS-CoV-2 infection, a condition referred to as long...

Decreased functional connectivity in post-COVID syndrome patients with high neuroinflammatory activity INTRODUCTION Previous research suggests some post-COVID patients with neurocognitive complaints (NCC) show neuroinflammation. Like in inflammatory diseases, this may affect network...

Abstract Background: Research from neuroendocrine challenge and other indirect studies has suggested increased central 5-HT function in chronic fatigue syndrome (CFS) and increased 5-HT1A receptor sensitivity. We assessed brain 5-HT1A receptor binding potential directly using the specific...

Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies Nociplastic pain has recently been introduced as a third entity for identifying patients suffering from chronic pain that arises from altered nociception...

Persistent lung and vascular inflammation in mild to moderate COVID-19 survivors detected by ¹⁸F-FDG PET/CT: A quantitative imaging study with implications for cardiovascular risk PURPOSE Lingering inflammation after COVID-19 has been proposed as a contributor to long-term cardiovascular risk...

Systemic increase of AMPA receptors associated with cognitive impairment of long COVID Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and...

CD38-specific immunoPET imaging for multiple myeloma diagnosis and therapeutic monitoring: preclinical and first-in-human studies PURPOSE CD38 is a glycoprotein highly specific to multiple myeloma (MM). Therapeutics using antibodies targeting CD38 have shown promising efficacy. However, the...

Choroid plexus alterations in autism spectrum disorder: A PET-MRI study The choroid plexus (CP), primarily known as the production site of cerebrospinal fluid (CSF), constitutes one of the sites of the blood-CSF barrier and plays a unique role in inflammation propagation, serving as a key...

PET Imaging of Innate Immune Activation Using 11C Radiotracers Targeting GPR84 Chronic innate immune activation is a key hallmark of many neurological diseases and is known to result in the upregulation of GPR84 in myeloid cells (macrophages, microglia, and monocytes). As such, GPR84 can...

Abstract: Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating condition with a large proportion of patients that experience orthostatic intolerance (OI). This systematic review aimed to assess whether cerebral blood flow (CBF) is reduced in ME/CFS...

Evidence for a role of skull bone marrow in human chronic pain as revealed by TSPO PET imaging The skull bone marrow is emerging as a critical hub for neuroimmune signaling in various disorders, with the potential to reshape how we understand brain-immune interactions. However, its role in...

Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing Manganotti, Paolo; Iscra, Katerina; Furlanis, Giovanni; Michelutti, Marco; Miladinović, Aleksandar; Menichelli, Alina; Cerio, Ivan; Accardo, Agostino; Dore, Franca; Ajčević, Miloš Cognitive...

[68Ga]FAPI PET/CT reveals increased pulmonary fibroblast activation protein expression in long COVID patients after ICU discharge B. van Leer, M. Londema, Ö. Kasalak, J. H. van Snick, M. L. Duiverman, J. C. Kuijvenhoven, M. D. de Kruif, D. E. Oprea-Lager, K. Pabst, M. E. Hellemons, H. H...

Prevalence of Persistent Cardiovascular and Pulmonary Abnormalities on PET/MRI and DECT Imaging in Long COVID Patients Maria Giovanna Trivieri; Ana Devesa; Philip M. Robson; Sonali Bose; Busra Cangut; Steve Liao; Audrey Kaufman; Renata Pyzik; Valentin Fauveau; Jamie Wood; Aaron Shpiner; Edwin...

Reorganization of brain connectivity in post-COVID condition: a 18F-FDG PET study Verger, Antoine; Doyen, Matthieu; Heyer, Sebastien; Goehringer, François; Bruyere, Alexandra; Kaphan, Elsa; Chine, Meriem; Menard, Amélie; Horowitz, Tatiana; Guedj, Eric A hypometabolic brain pattern has been...

Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease McFadden; Matthews; Scott; Herholz; Dickie; Haroon; Sparasci; Ahmed; Kyrtata; Parker; Emsley; Handley; Lohezic; Parkes Cerebrovascular disease is an important contributor to dementia with...

Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics Talkington, Grant McGee; Kolluru, Paresh; Gressett, Timothy E.; Ismael, Saifudeen; Meenakshi, Umar; Acquarone, Mariana; Solch-Ottaiano, Rebecca J.; White, Amanda...

Abstract Imaging inflammation holds immense potential for advancing the diagnosis, treatment and prognosis of many conditions. The lack of a specific and sensitive positron emission tomography (PET) probe to detect inflammation is a critical challenge. To bridge this gap, we present CD45-PET...

Assessment of Myocardial 18F-FDG Uptake at PET/CT in Asymptomatic SARS-CoV-2–vaccinated and Nonvaccinated Patients Authors: Takehiro Nakahara et al Published Online: Sep 19 2023 Abstract Background Patients who developed myocarditis after SARS-CoV-2 vaccination show abnormalities on cardiac...