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PACE trial graphs and gifs

Discussion in 'PsychoSocial ME/CFS Research' started by Lucibee, Jul 3, 2018.

  1. Lucibee

    Lucibee Senior Member (Voting Rights)

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    I've created this thread as a repository for user-generated graphs and gifs related to the PACE trial.
     
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  2. Lucibee

    Lucibee Senior Member (Voting Rights)

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    Here is my gif of 6mWT vs PF for all groups. Data missing at the end is shown in red at the start.

    PACE_PFvsWT_all.gif
     
  3. Andy

    Andy Committee Member & Outreach

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    I know 6mWT stands for 6 minutes Walk Test but what does PF stand for please?
     
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  4. Trish

    Trish Moderator Staff Member

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    PF is SF-36 Physical Functioning questionnaire.
     
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  5. Clara

    Clara Established Member (Voting Rights)

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    @Lucibee What software did you use to make the charts? Thanks!
     
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  6. Lucibee

    Lucibee Senior Member (Voting Rights)

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    Excel for the multiple timepoints and graphs. Then hours and hours (yawn) of cutting and pasting into Powerpoint (and swearing when things didn't line up properly). Then saved as WMV file (from slide show). Then uploaded to a WMV to GIF converter online.
     
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  7. sea

    sea Senior Member (Voting Rights)

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    Sorry I don’t understand the point of the gif. Because it moves while I’m trying to work out what the charts show I can’t make any sense of it at all.
     
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  8. Hutan

    Hutan Moderator Staff Member

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    The distance walked in 6 minutes is on the y axis. The SF-36 Physical function score (as per Graham's first video) is on the x axis.

    And the four graphs are for each of the separate treatments.

    A particular blue dot is for a particular participant. The start point is the combination of walk time and physical function score at the beginning of the trial. And that blue dot moves through the data recorded for that one person throughout the trial.

    The red dots are for the participants who had missing data (I'm not sure if that was just missing data at the end of trial?).

    If the objective and subjective measures are telling the same positive story, then there should be movement towards the top right corner over time.

    @Lucibee, could you also show your data as 4 line charts, with the trajectories of each participant shown as a line? (Maybe lines going backwards (to the bottom or the left) would have to be shown in a different colour?)
     
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  9. rvallee

    rvallee Senior Member (Voting Rights)

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    If you have more data I could probably help you cut that workload significantly. I was a software developer. I particularly dealt with data manipulation, representation, conversion and display. I work much slower than before but the knowledge is still all there.
     
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  10. Lucibee

    Lucibee Senior Member (Voting Rights)

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    Unfortunately (or maybe fortunately), I didn't have the interim data, so I suspect each blue dot jumps around an awful lot in reality (as @Graham found with the FINE data).
     
  11. Lucibee

    Lucibee Senior Member (Voting Rights)

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    Just having start and end points in different colours would do it. I'll see if I can work out how to get Excel to do that - but it will be messy.
    I thought the movement was helpful to show how similar the groups were.
     
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  12. Hutan

    Hutan Moderator Staff Member

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    Yes, sorry, I thought later I should have said how good your charts are. It's just that maybe a static version might be good for people who have a harder time with movement and it also might be another interesting way to look at the data.

    I think having the improving lines and the worsening lines in different colours would give a good visual sense of what was going on. But conditional formatting of each participant's series in the chart would take some working out; I'm not sure if it could be automated. If not, that is a tedious job.
     
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  13. Graham

    Graham Senior Member (Voting Rights)

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    Actually, I love the GIF. You need to look at it a lot of times to see various patterns emerge. For example, they all have points which drop, either on the sf-36 PF or on the 6-min walk, but, credit to GET, not many of those patients drop their walking distance, but does have several dropping on the PF. In contrast, "scaredy-cat" APT does have quite a few dropping both ways.

    There are also some interesting anomolies, such as one on the SMC group which increases the walking distance to pretty good, but drops a lot on the PF.
     
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  14. Lucibee

    Lucibee Senior Member (Voting Rights)

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    Here are graphs specific to the GET arm. I've posted the gif and the graph I put together to show that data are NOT missing at random - ie, I suspect that 6mWT results for GET group were biased towards those with better PF at the end of the trial.

    PACE_PFvsWT_GET.gif
    6minWTmissing.png
     
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  15. Barry

    Barry Senior Member (Voting Rights)

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    There is the potential for some sort of aliasing effect if not careful I imagine, where one blue dot could newly occupy the space someone else's blue dot previously occupied or looked likely to occupy, but the moving images make it pretty clear to see for some dots at least.
     
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  16. Trish

    Trish Moderator Staff Member

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    @Lucibee, that's excellent thank you.
     
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  17. Graham

    Graham Senior Member (Voting Rights)

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    Many years ago, when I was a mere slip of a lad, there was a computer called an Amiga, and some graphic software that did "tweening". You plotted where a point started and where it ended, then it moved from one to the other according to the type of movement you wanted. I think our Amiga had 2 Meg of memory.

    These days you need relatively sophisticated software with Gigs of memory to do it. I use Cheeta3D. I used to be able to do it on an older version of Photoshop, but my current "upgraded" version no longer offers that. What did you use @Lucibee ?
     
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  18. Lucibee

    Lucibee Senior Member (Voting Rights)

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  19. Barry

    Barry Senior Member (Voting Rights)

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    But they seemed to still report they were improved or about the same, which in terms of PF/6mwt still shows the same inflationary trend.
     
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  20. Graham

    Graham Senior Member (Voting Rights)

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    Sorry @Lucibee ! I saw in the later post that you used Excel, but couldn't work out what you used to create the animated Gif.

    With Cheetah3D you don't have a graphing option, so you have to plot each point by hand (well, if you scale it properly, you have to specify each co-ordinate), but the animation and video are automatic. The trouble is that the learning curve is steep. Luckily I have a live-in graphic tutor, otherwise known as a son.
     
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