Oxaloacetate

[Mij]

Oxaloacetate pills are hard to find, I have only seen Benagene brand available and it gets expensive really quickly as someone pointed out. I had more or less the same results or actually better just by consuming spinach (aka the Popeye protocol). Spinach contains oxalic acid or oxalate, so not exactly the same compound, but you get around 1000 mg oxalic acid in 100 gram spinach, which costs a couple of dollars or less.

This is the supplement that Kaufman used for his patients.

 

[5vforest]

Promoted on Facebook from the company that makes the supplement... I'm not really sure about this.

 

[Hutan]

Links to forum threads on

one completed study:
Oxaloacetate Treatment For Mental And Physical Fatigue In (ME/CFS) and Long-COVID fatigue patients, 2022, Cash and Kaufman
tldr (study has many issues, not least of which is that the data was analysed only by the person (Cash) who stands to benefit from finding a positive result from the supplement.)

one study underway:
USA: RESTORE ME: A RandomizEd Double Blind Placebo Control Trial to Determine the EffectS of OxaloaceTate On ImpRoving FatiguE in ME/CFS

Couldn’t there be another metabolite, that is a precursor to oxaloacetate, that is cheaper?

Well what about potato?

. Had me laughing out loud in March, had me laughing out loud again in July.

 

[Mij]

Using the potato analogy before anything even begins to occur, needs to be washed, peeled, chopped, salted, oiled, cooked and then hope for the best.

 

[Milo]

Oxaloacetate CFS is branded only for ME (and now long-Covid), and one bottle of it will set you back 500$usd and you will need a new bottle every 6 weeks. https://benagene.com/products/oxaloacetate-cfs#

 

[perchance dreamer]

I used to take oxaloacetate from Sabre Sciences's Cereze, since discontinued. It seemed to help my cognition, but I stopped taking it because I realized it was contributing to insomnia.

 

[NelliePledge]

Oxaloacetate CFS is branded only for ME (and now long-Covid), and one bottle of it will set you back 500$usd and you will need a new bottle every 6 weeks. https://benagene.com/products/oxaloacetate-cfs#

So around 4.5k dollars over a year. Someone must be making quite a bit of money there.

 

[Braganca]

https://meassociation.org.uk/2024/1...oxaloacetate-for-improving-fatigue-in-me-cfs/

Results
Anhydrous enol-oxaloacetate (oxaloacetate) was well tolerated at the doses tested. Oxaloacetate significantly lowered fatigue from baseline by >25%, whereas the control group was not significant at ~10% reduction.

https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1483876/abstract

 

[forestglip]

https://meassociation.org.uk/2024/1...oxaloacetate-for-improving-fatigue-in-me-cfs/

Results
Anhydrous enol-oxaloacetate (oxaloacetate) was well tolerated at the doses tested. Oxaloacetate significantly lowered fatigue from baseline by >25%, whereas the control group was not significant at ~10% reduction.

https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1483876/abstract

Thanks for posting. I made a thread:

RESTORE ME: A RCT of Oxaloacetate for Improving Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2024, Cash et al

 

[Mij]

I'm not willing to dish out this amount of money to improve fatigue even though my Oxa levels are very low. I have periods when I'm feeling almost normal with very little fatigue.

 

[bobbler]

Oxaloacetate pills are hard to find, I have only seen Benagene brand available and it gets expensive really quickly as someone pointed out. I had more or less the same results or actually better just by consuming spinach (aka the Popeye protocol). Spinach contains oxalic acid or oxalate, so not exactly the same compound, but you get around 1000 mg oxalic acid in 100 gram spinach, which costs a couple of dollars or less.

Oh goodness please don't tell me I've lost these decades and it could have all been so different if only I'd loved spinach?

 

[Jonathan Edwards]

Oxalate and oxaloactate are completely different chemicals. They just have rather similar names.

It is almost like uric acid and urea, which sound similar, but only because they are both named after where you find them - urine.