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Open USA: RESTORE ME: A RandomizEd Double Blind Placebo Control Trial to Determine the EffectS of OxaloaceTate On ImpRoving FatiguE in ME/CFS

Discussion in 'Recruitment into current ME/CFS research studies' started by Andy, Jun 18, 2022.

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  1. Andy

    Andy Committee Member

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    The Bateman Horne Center is working with Terra Biological to test oxaloacetate, a nutritional supplement, in ME/CFS. Oxaloacetate is an energy metabolite that holds a key place in the TCA cycle – the cycle that is essential for the generation of energy. Half of the participants will receive capsules containing oxaloacetate and half will receive capsules with rice flour which will serve as the placebo.

    The trial will last for 90 days. During this time there will be four (4) in-person visits to the Bateman Horne Center for a physical exam, assessments, blood collection, and fitted with a device to measure daily steps and upright position. Participants will be emailed short surveys to complete on a weekly basis throughout the trial. At the end of the study, participants that received a placebo will be provided with a 90-day trial of oxaloacetate if they are interested. Eligible participants will be compensated $50 for each in-person visit.

    If you are interested in learning more about this study, please contact us by:

    Emailing: research@batemanhornecenter.org or call (801) 532-8311

    https://batemanhornecenter.org/research/#active-recruiting
     
  2. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    Someone needs their acronym privileges removed!

    Oxaloacetate is part of the citric acid cycle, but I am not overly confident this will have much effect.
     
  3. Trish

    Trish Moderator Staff Member

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  4. MEMarge

    MEMarge Senior Member (Voting Rights)

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    "Citric acid is a so-called tricarboxylic acid, containing three carboxyl groups (COOH). Hence the Krebs cycle is sometimes referred to as the tricarboxylic acid (TCA) cycle."

    When I did my degree in Physiology and Biochemistry many years ago it was mainly called the Krebs cycle.[/QUOTE]

    I doubt it will have much effect either, especially if the problem is at the level of pyruvate dehydrogenase,as a couple of researchers have thought
     
  5. Sarah94

    Sarah94 Senior Member (Voting Rights)

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    Possibly the most cringe-inducing study acronym that I've seen in ages
     
  6. Sarah94

    Sarah94 Senior Member (Voting Rights)

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    Sorry, I meant CRYING: Possibly the most Cringe-inducing study acRonYm that I've seeN in aGes
     
    obeat, Joan Crawford, Hutan and 11 others like this.
  7. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    You get to keep your acronym privileges!
     
  8. Andy

    Andy Committee Member

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    Some alternatives, generated by https://acronymify.com/

    TIRESOME - TrIal deteRmine EffectS Oxaloacetate ME/cfs
    MEDDLESOME - randoMizED Double bLind EffectS Oxaloacetate ME/cfs
    MEDIOCRE - randoMizEd Double blInd placebO Control tRial mE/cfs
    IRRITATE - randomIzed tRial deteRmIne effecTs oxAloacetaTe mE/cfs
    DOMINATRICES - ranDOMized blINd plAcebo conTrol tRial determIne effeCts oxaloacEtate me/cfS
     
    RedFox, obeat, Sean and 23 others like this.
  9. Trish

    Trish Moderator Staff Member

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    Thanks, Andy, that's hilarious.
     
    MEMarge, JemPD, Johanna WJ and 4 others like this.
  10. cassava7

    cassava7 Senior Member (Voting Rights)

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    Reposting @LarsSG’s post on the thread on Dr Kaufman’s oxaloacetate trial:
    This sounds very unpromising.
     
  11. Trish

    Trish Moderator Staff Member

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    RedFox likes this.
  12. Joan Crawford

    Joan Crawford Senior Member (Voting Rights)

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    Brilliant Andy.
     
    MEMarge, RedFox and Trish like this.

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