Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

[Nightsong]

It's up!

Abstract:
Evidence bearing on possible mechanisms for the clinical syndrome of ME/CFS is reviewed. The evidence is used to argue for a hypothesis that centres on a form of persistent, inappropriate, ‘neuroimmune hypervigilance’ mediated primarily by T lymphocyte-macrophage interaction but influenced by IgG antibody binding to the gamma interferon-inducible high affinity immunoglobulin receptor FcγRI. This proposed mechanism could explain why the illness resembles post-infective T cell-mediated autoinflammatory syndromes in age of onset and time course but has a female preponderance similar to autoantibody-mediated disease.

Link | PDF

 

[Kitty]

Oooh!

Am now at the moment when, after all the anticipation, I remember I'm not going to understand a word of it.

 

[Utsikt]

Psychological approaches to central nervous processes have proven unhelpful (see [16])

Enough said, really!

I think the wordings in the intro are going to be very useful for researchers needing a short intro that doesn’t go beyond the evidence.

 

[Hutan]

We've made a new thread for the paper:
A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

We've moved this thread to Research News and have closed it.