Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

Moot I think. Depends on how modular and heterogeneous things turn out to be maybe.

 

Complex pathways you say…


Image source and more information here.

Or slightly less scarily ‘what is an interferon?’

 

Same.

 

I don't know if this question has been asked but can you distinguish which of the two ME types are affected by their ME being triggered by a cold or virus and then also can be seemingly switched off for time by a cold or Covid. Would this occurrence still apply to both types of ME or one in particular?

 

I am not saying there are two or three or six, just that there may be relatively separate groups, as a caution to lumping everyone together with one explanation.

 

Chapter 29 of the Kurzgesagt book and now I know what an interferon is (they're amazing!). I now understand two words of the title!

Short chapters, easy read, nice pictures - join me, fellow biology neophytes! There's still time!

 

Nice work @Sasha

I’m just doing names for now.. how about

Interferon Mediated T-cell Involved Resource Exhausting Disease

Yes, I’m Tired

 

I cannot stand the Kurzgesagt book, too many errors and misinformation in the autoimmunity section in particular. I think wikipedia is more accurate and valuable to learn from.

 

Sort of like an Alfa Romeo….. a bit late but probably worth it.

 

Several new papers have been posted on Qeios today but I haven't seen this one yet.

 

good to know that I am not the only one that can't think about anything else

 

Noooooooooooo

 

They’re probably confused at all these hits to their archive page… refreshing looking for new papers. At least we know someone has found the admin password and they’re up and running again!

 

I bet the moment I go to bed tonight it will be published. It is just after 7pm NZ time right now. I wonder if I pretend to go to bed early it will come out sooner?

 

When I'm waiting for something like that, I like to think of sleep as time travel - close my eyes and it will instantly be seven hours later...

 

Don't worry Sasha. The fun of science is unlearning all the stuff you thought you had learnt.
Most of the pure factual content will be OK but the story built around it will be full of mistakes. The fun is finding the mistakes and replacing them with something useful.

 

TBH, I was already wondering if dendritic cells don't really present antigens in hot-dog buns...

 

Oh, that bit is exactly right.