Researching ME/CFS has been hard, in part, because there isn't always "obvious" areas to look and the symptoms are often global. I'm proposing an area of research that might be of interest is non-allergic rhinitis. I have this in chronic, un-remitting form not caused by allergies, and which accompanied the onset of my ME/CFS. There is one smallish study by Baraniuk that found 46% of patients have non-allergic rhinitis. I've noticed many patients with similar problems on the forums. And I think, in part, this adds to the patient's perception of an ongoing "flu" or immunological pathology. After all, fatigue and sinus congestion are what we think of most when we think of the flu. However, there is also research that neurological mechanisms can cause some forms non-allergic rhinits. So, it seems to be like an interesting and possible fruitful way to find tangible research progress as Braniuk says, I've never seen any research following this - a place in the body where you can actually see something is tangible wrong, and the mechanisms defunct. Biopsies can be made (mast cells, histamine, eusonophils, cytokines etc.). Receptors profiled with medications like lidocaine and capsaicin. I might be interested in trying to get researches involved in this topic if others feel the same way. For simplicity, I'd like to keep this thread about the theory and population impacts of rhinitis rather than personal experience. I will make this thread on PR as well, when I have recovered some energy Continuations; There are 7 classical NARs, but a new one emerging is autonomic NAR (also called vasomotor rhinitis). This is a recent study on it. I actually disagree with the authors speculation that GERD causes it, since I have adressed that symptom well. I think it's more likely autonomic dysfunction causes both GERD and NAR. So it may be that NAR is a symptom of autonomic dysfunction in those with ME/CFS. Would this make it redundant to study? Or would it offer greating understanding to the autonomic features of ME/CFS?