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New MRT Imaging Biomarkers and Treatment With Kinetic Oscillatory Stimulation (KOS) in Nasal Cavity for ME/CFS, underway, Karolinska University

Discussion in 'BioMedical ME/CFS Research' started by Sly Saint, Apr 19, 2018.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    New MRT Imaging Biomarkers and Treatment With Kinetic Oscillatory Stimulation (KOS) in Nasal Cavity for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

    Published on BioPortfolio: 2018-04-19T10:10:22-0400

    https://www.bioportfolio.com/resour...h-Kinetic-Oscillatory-Stimulation-KOS-in.html

    Sponsor:
    Karolinska University Hospital
    Information provided by (Responsible Party):
    Tie-Qiang Li, Karolinska University Hospital


    Recruitment Status : Recruiting
    Estimated Primary Completion Date : December 31, 2019
    Estimated Study Completion Date : June 15, 2020

    https://clinicaltrials.gov/ct2/show/results/NCT03502044?view=results



     
    Hutan, Andy, Amw66 and 7 others like this.
  2. strategist

    strategist Senior Member (Voting Rights)

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    Someone explain this to me please. They do what with the nose?
     
  3. Wonko

    Wonko Senior Member (Voting Rights)

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    Sounds like basically just the tapping "therapy" using some gizmo to tap inside the nose, just so it's more "scientific" and also so people need to buy their gizmo. Oh there'll be frequencies and amplitudes and stuff, but......

    (not that I know anything about it but the idea that ME can be cured by tapping, makes me want to stand on a circle and shout things)
     
  4. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    To be double blind, they would need to stimulate the autonomic nervous system without the person noticing. That seems quite a hard thing to do. Generally speaking stimulation of the autonomic nervous system produces obvious symptoms, like diarrhoea or fainting or a cold sweat!
     
    Hutan, glennthefrog, EzzieD and 7 others like this.
  5. Mattie

    Mattie Senior Member (Voting Rights)

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    Inara and Wonko like this.
  6. Allele

    Allele Senior Member (Voting Rights)

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    I wonder what made them think a vibrating ballon catheter for treating rhinitis would effectively treat ME? I mean, that would be great, but, erm, unlikely.
     
    Hutan, hinterland, EzzieD and 6 others like this.
  7. Barry

    Barry Senior Member (Voting Rights)

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    Not sure about the ethics of this suggestion, but if you did stimulate the autonomic nervous system in that way, could you accompany it with an inert pill, but tell the trial participants it might have side effects akin to your "obvious symptoms"? Or am I missing the point here?
     
    adambeyoncelowe likes this.
  8. Dancer

    Dancer Established Member (Voting Rights)

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    Seems like a gizmo is search of having therapeutic value to something (looks like they are proposing it to have value for migraines, and other conditions). I'd be glad to be proved wrong. I'll start wiggling my nose right now and see if I feel better. ;-)
     
  9. Sunshine3

    Sunshine3 Senior Member (Voting Rights)

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    Oh Lord, that has made me laugh!!
     
    adambeyoncelowe and Dancer like this.
  10. Sean

    Sean Senior Member (Voting Rights)

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    Not my first choice of anatomical sites to apply a vibrating object to produce a happy ending. :whistle:
     
    glennthefrog, Hipsman, Hutan and 8 others like this.
  11. mango

    mango Senior Member (Voting Rights)

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    Dr Per Julin, the study director, is one of the very best biomedical ME specialists there are in Sweden, so this is definitely no joke :)
     
    MEMarge, glennthefrog, Hutan and 5 others like this.
  12. mango

    mango Senior Member (Voting Rights)

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    Their application to the ethics review board has a lot of details about the hows and the whys (47 pages, all in Swedish).

    Here are some excerpts:

    kos1.png
    kos2.png
    kos3.png

    (Edited to replace image links with uploaded image files.)
     
    Last edited: Apr 20, 2018
  13. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    Those Photobucket images aren't showing up?
     
    Sly Saint and Mattie like this.
  14. TiredSam

    TiredSam Moderator Staff Member

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    Perhaps we shouldn't be so sniffy? Maybe it isn't an idea to be sneezed at?
     
    MEMarge, Hutan, EzzieD and 9 others like this.
  15. Sean

    Sean Senior Member (Voting Rights)

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    Gets up my nose.
     
    Snow Leopard, Hutan, TiredSam and 2 others like this.
  16. mango

    mango Senior Member (Voting Rights)

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    Sorry! Thanks for letting me know. They did show up for me earlier today, I'm not sure what changed? I've edited my post now. Are the images showing up now?
     
    Sly Saint and adambeyoncelowe like this.
  17. Allele

    Allele Senior Member (Voting Rights)

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    they are for me :thumbup:
     
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  18. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    Yes. Still can't understand 'em, like! ;)
     
    mango likes this.
  19. Cheshire

    Cheshire Moderator Staff Member

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    This study has now been published. Thread there.
     
    rvallee, Hutan, Wonko and 3 others like this.

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