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miRNA profiling of circulating EVs in (ME/CFS), 2018, Almenar-Pérez et al

Discussion in 'BioMedical ME/CFS Research' started by Andy, Feb 3, 2019.

  1. Andy

    Andy Committee Member & Outreach

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    Abstract only, or it's a poster presentation?
    https://search.proquest.com/openvie...f68f104f30/1?pq-origsite=gscholar&cbl=2030046
     
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  2. Trish

    Trish Moderator Staff Member

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    It's in the Journal of Extracellular Vesicles supplement and is described as a Document preview.
    It looks like a follow up to this paper last year which was a pilot study that looked at extracellular vesicles in blood and found slightly more of them and they were significantly smaller in pwME. It was a small pilot study.

    The one on this thread is about the downregulation of miRNA's in EV's and PBMC's. (I say that as if I know what I'm talking about!).

    Looks like an area that needs lots more research and might prove significant.
     
    Last edited: Feb 4, 2019
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  3. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    Dr. Maureen Hanson is also looking at EV's as part of her NIH center grant.
    Link : http://news.cornell.edu/stories/2017/09/94m-nih-grant-funds-chronic-fatigue-syndrome-center
     
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  4. Andy

    Andy Committee Member & Outreach

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    One of the authors of this is from Hanson's team, Lubov Nathanson.
     
  5. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    Lubov Nathanson is shown in the PDF as belonging to NOVA. That would be Klimas's team.
     
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  6. boolybooly

    boolybooly Established Member (Voting Rights)

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    So thinking out loud does this follow from previous miRNA / NK & CD8(+)T cell studies of Marshall-Gradisnik & Staines et al ?

    2012
    https://www.researchgate.net/public...nic_Fatigue_SyndromeMyalgic_Encephalomyelitis
    2014
    https://www.researchgate.net/public...nic_Fatigue_SyndromeMyalgic_Encephalomyelitis
    (As an aside, its good practice to spell out acronyms at least once in any document using them. In this case EV presumably means Extracellular Vesicles, but the same abbreviation is also used to mean EnteroVirus so it could be confusing.)
     
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  7. Trish

    Trish Moderator Staff Member

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    I agree, though in this case the abstract is in the Journal of Extracellular Vesicles, so I guess they could reasonably assume their readers knew what they meant by EV.
     
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  8. shak8

    shak8 Senior Member (Voting Rights)

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    Excited by this!
     
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