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Circulating extracellular vesicles as potential biomarkers in CFS (2018) Castro-Marrero et al

Discussion in 'BioMedical ME/CFS Research' started by Kalliope, Mar 27, 2018.

  1. Kalliope

    Kalliope Senior Member (Voting Rights)

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    Kalliope, Mar 27, 2018
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  2. Trish

    Trish Moderator Staff Member

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    I have no idea what this means in terms of understanding ME, and it's a tiny study, but the differences found in quantity and size of EV's is surprisingly different. Maybe a biomarker? Early days, of course.
     
    Trish, Mar 27, 2018
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  3. Diwi9

    Diwi9 Senior Member (Voting Rights)

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    Dr. Maureen Hanson states in this talk that she will be doing a study that examines extracellular vesicles:
     
    Diwi9, Mar 27, 2018
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  4. Amw66

    Amw66 Senior Member (Voting Rights)

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    Replication?
     
    Amw66, Mar 27, 2018
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  5. Trish

    Trish Moderator Staff Member

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    Thanks for that @Diwi9. Really interesting - they are going to look at EV's as part of their 2day CPET study of all sorts of things in blood and brains before and after exercise challenge.
     
    Trish, Mar 27, 2018
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  6. Dancer

    Dancer Established Member

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    Since I'd never heard of EV's, I did a quick google and see that they are being studied as markers in cancer, aging and other things. So perhaps it's more of a general "something wrong in the body" marker than an ME/CFS biomarker, but it still adds to the picture of the physical debility we have and might help measure if some intervention brings improvement or deterioration.
     
    Dancer, Mar 27, 2018
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  7. John Mac

    John Mac Established Member (Voting Rights)

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    From a Cort blog

    https://www.healthrising.org/blog/2017/09/30/three-nih-funded-mecfs-research-centers-controversy/
     
    John Mac, Mar 27, 2018
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  8. Hutan

    Hutan Moderator Staff Member

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    https://www.s4me.info/threads/devel...ronic-fatigue-syndrome-me-cfs.965/#post-16364

    A post by @strategist in November 2017 - Watanabe's team is on to EV's too.

    Watanabe et al. have received funding to conduct a 120 participants PET brain imaging study.

    The primary outcome:
    The level of brain positive inflammation dected by positron emission tomography (PET), [F18]DPA-714

    Secondary outcomes:
    Oxidative stress level, Anti-oxidant activity, Metabolome, Proteome, Cytokines, Extracellular vesicles, Clinical test (CRP, cholesterol, etc.), CD antibody, Autonomic nervous system, Questionnaires for fatigue, depression and various symptoms, Arithmetic task, Sleep-wake cycle, Performance status for fatigue

    Details https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033257​
     
    Hutan, Mar 28, 2018
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  9. Sean

    Sean Senior Member (Voting Rights)

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    Now this is interesting. I have long wondered if the extra-cellular matrix was playing a role.
     
    Sean, Mar 28, 2018
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