1. Guest, click here to read the 'News in Brief' post for w/c 13th May.
    Dismiss Notice

Circulating extracellular vesicles as potential biomarkers in CFS (2018) Castro-Marrero et al

Discussion in 'BioMedical ME/CFS Research' started by Kalliope, Mar 27, 2018.

  1. Kalliope

    Kalliope Senior Member (Voting Rights)

    Messages:
    1,914
    Likes Received:
    20,010
    Location:
    Norway
    Hutan, Aroa, Sly Saint and 14 others like this.
  2. Trish

    Trish Moderator Staff Member

    Messages:
    12,050
    Likes Received:
    66,886
    Location:
    UK
    I have no idea what this means in terms of understanding ME, and it's a tiny study, but the differences found in quantity and size of EV's is surprisingly different. Maybe a biomarker? Early days, of course.
     
    Daisymay, Jan, Barry and 4 others like this.
  3. Diwi9

    Diwi9 Senior Member (Voting Rights)

    Messages:
    160
    Likes Received:
    1,412
    Dr. Maureen Hanson states in this talk that she will be doing a study that examines extracellular vesicles:
     
    Hutan, Daisymay, mango and 7 others like this.
  4. Amw66

    Amw66 Senior Member (Voting Rights)

    Messages:
    1,653
    Likes Received:
    9,620
    Replication?
     
    Daisymay, Jan, Barry and 2 others like this.
  5. Trish

    Trish Moderator Staff Member

    Messages:
    12,050
    Likes Received:
    66,886
    Location:
    UK
    Thanks for that @Diwi9. Really interesting - they are going to look at EV's as part of their 2day CPET study of all sorts of things in blood and brains before and after exercise challenge.
     
    Daisymay, mango, Hutan and 6 others like this.
  6. Dancer

    Dancer Established Member (Voting Rights)

    Messages:
    32
    Likes Received:
    340
    Location:
    Midwest, USA
    Since I'd never heard of EV's, I did a quick google and see that they are being studied as markers in cancer, aging and other things. So perhaps it's more of a general "something wrong in the body" marker than an ME/CFS biomarker, but it still adds to the picture of the physical debility we have and might help measure if some intervention brings improvement or deterioration.
     
    Daisymay, JaimeS, Jan and 6 others like this.
  7. John Mac

    John Mac Senior Member (Voting Rights)

    Messages:
    140
    Likes Received:
    1,571
    From a Cort blog

    https://www.healthrising.org/blog/2017/09/30/three-nih-funded-mecfs-research-centers-controversy/
     
    Daisymay, Hutan, Jan and 7 others like this.
  8. Hutan

    Hutan Moderator Staff Member

    Messages:
    4,223
    Likes Received:
    19,525
    https://www.s4me.info/threads/devel...ronic-fatigue-syndrome-me-cfs.965/#post-16364

    A post by @strategist in November 2017 - Watanabe's team is on to EV's too.

    Watanabe et al. have received funding to conduct a 120 participants PET brain imaging study.

    The primary outcome:
    The level of brain positive inflammation dected by positron emission tomography (PET), [F18]DPA-714

    Secondary outcomes:
    Oxidative stress level, Anti-oxidant activity, Metabolome, Proteome, Cytokines, Extracellular vesicles, Clinical test (CRP, cholesterol, etc.), CD antibody, Autonomic nervous system, Questionnaires for fatigue, depression and various symptoms, Arithmetic task, Sleep-wake cycle, Performance status for fatigue

    Details https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033257
     
    John Mac, Daisymay, Diwi9 and 5 others like this.
  9. Sean

    Sean Senior Member (Voting Rights)

    Messages:
    1,486
    Likes Received:
    12,328
    Now this is interesting. I have long wondered if the extra-cellular matrix was playing a role.
     
    Daisymay, adambeyoncelowe and Trish like this.

Share This Page