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Circulating extracellular vesicles as potential biomarkers in CFS (2018) Castro-Marrero et al

Discussion in 'ME/CFS research' started by Kalliope, Mar 27, 2018.

  1. Kalliope

    Kalliope Senior Member (Voting Rights)

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  2. Trish

    Trish Moderator Staff Member

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    I have no idea what this means in terms of understanding ME, and it's a tiny study, but the differences found in quantity and size of EV's is surprisingly different. Maybe a biomarker? Early days, of course.
     
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  3. Diwi9

    Diwi9 Senior Member (Voting Rights)

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  4. Amw66

    Amw66 Senior Member (Voting Rights)

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  5. Trish

    Trish Moderator Staff Member

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    Thanks for that @Diwi9. Really interesting - they are going to look at EV's as part of their 2day CPET study of all sorts of things in blood and brains before and after exercise challenge.
     
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  6. Dancer

    Dancer Established Member (Voting Rights)

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    Since I'd never heard of EV's, I did a quick google and see that they are being studied as markers in cancer, aging and other things. So perhaps it's more of a general "something wrong in the body" marker than an ME/CFS biomarker, but it still adds to the picture of the physical debility we have and might help measure if some intervention brings improvement or deterioration.
     
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  7. John Mac

    John Mac Senior Member (Voting Rights)

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    From a Cort blog

    https://www.healthrising.org/blog/2017/09/30/three-nih-funded-mecfs-research-centers-controversy/
     
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  8. Hutan

    Hutan Moderator Staff Member

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    https://www.s4me.info/threads/devel...ronic-fatigue-syndrome-me-cfs.965/#post-16364

    A post by @strategist in November 2017 - Watanabe's team is on to EV's too.

    Watanabe et al. have received funding to conduct a 120 participants PET brain imaging study.

    The primary outcome:
    The level of brain positive inflammation dected by positron emission tomography (PET), [F18]DPA-714

    Secondary outcomes:
    Oxidative stress level, Anti-oxidant activity, Metabolome, Proteome, Cytokines, Extracellular vesicles, Clinical test (CRP, cholesterol, etc.), CD antibody, Autonomic nervous system, Questionnaires for fatigue, depression and various symptoms, Arithmetic task, Sleep-wake cycle, Performance status for fatigue

    Details https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033257
     
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  9. Sean

    Sean Senior Member (Voting Rights)

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    Now this is interesting. I have long wondered if the extra-cellular matrix was playing a role.
     
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