1. Guest, the 'News in Brief' for the week beginning 30th January 2023 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Circulating extracellular vesicles as potential biomarkers in CFS (2018) Castro-Marrero et al

Discussion in 'ME/CFS research' started by Kalliope, Mar 27, 2018.

  1. Kalliope

    Kalliope Senior Member (Voting Rights)

    Messages:
    5,572
    Location:
    Norway
    Hutan, Aroa, Sly Saint and 14 others like this.
  2. Trish

    Trish Moderator Staff Member

    Messages:
    44,609
    Location:
    UK
    I have no idea what this means in terms of understanding ME, and it's a tiny study, but the differences found in quantity and size of EV's is surprisingly different. Maybe a biomarker? Early days, of course.
     
    Daisymay, Jan, Barry and 4 others like this.
  3. Diwi9

    Diwi9 Senior Member (Voting Rights)

    Messages:
    160
    Hutan, Daisymay, mango and 7 others like this.
  4. Amw66

    Amw66 Senior Member (Voting Rights)

    Messages:
    5,493
    Daisymay, Jan, Barry and 2 others like this.
  5. Trish

    Trish Moderator Staff Member

    Messages:
    44,609
    Location:
    UK
    Thanks for that @Diwi9. Really interesting - they are going to look at EV's as part of their 2day CPET study of all sorts of things in blood and brains before and after exercise challenge.
     
    Daisymay, mango, Hutan and 6 others like this.
  6. Dancer

    Dancer Established Member (Voting Rights)

    Messages:
    48
    Location:
    Midwest, USA
    Since I'd never heard of EV's, I did a quick google and see that they are being studied as markers in cancer, aging and other things. So perhaps it's more of a general "something wrong in the body" marker than an ME/CFS biomarker, but it still adds to the picture of the physical debility we have and might help measure if some intervention brings improvement or deterioration.
     
    Daisymay, JaimeS, Jan and 6 others like this.
  7. John Mac

    John Mac Senior Member (Voting Rights)

    Messages:
    724
    From a Cort blog

    https://www.healthrising.org/blog/2017/09/30/three-nih-funded-mecfs-research-centers-controversy/
     
    Daisymay, Hutan, Jan and 7 others like this.
  8. Hutan

    Hutan Moderator Staff Member

    Messages:
    21,597
    Location:
    Aotearoa New Zealand
    https://www.s4me.info/threads/devel...ronic-fatigue-syndrome-me-cfs.965/#post-16364

    A post by @strategist in November 2017 - Watanabe's team is on to EV's too.

    Watanabe et al. have received funding to conduct a 120 participants PET brain imaging study.

    The primary outcome:
    The level of brain positive inflammation dected by positron emission tomography (PET), [F18]DPA-714

    Secondary outcomes:
    Oxidative stress level, Anti-oxidant activity, Metabolome, Proteome, Cytokines, Extracellular vesicles, Clinical test (CRP, cholesterol, etc.), CD antibody, Autonomic nervous system, Questionnaires for fatigue, depression and various symptoms, Arithmetic task, Sleep-wake cycle, Performance status for fatigue

    Details https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033257
     
    John Mac, Daisymay, Diwi9 and 5 others like this.
  9. Sean

    Sean Senior Member (Voting Rights)

    Messages:
    5,302
    Location:
    Australia
    Now this is interesting. I have long wondered if the extra-cellular matrix was playing a role.
     
    Daisymay, adambeyoncelowe and Trish like this.

Share This Page