1. The latest crowdfunder to support David Tuller's work has opened. To donate click here.
    Dismiss Notice
  2. Guest, the two part 'News in Brief' for the week beginning 11th October 2021 is here.
    Dismiss Notice
  3. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Metabolic profiling of an ME cohort reveals disturbances in fatty acid and lipid metabolism, Hanson, Levine et al, 2018

Discussion in 'BioMedical ME/CFS Research' started by Dr Carrot, Feb 2, 2018.

  1. Dr Carrot

    Dr Carrot Senior Member (Voting Rights)

    Messages:
    262
    Have had limited success with the search function here, so if this has been posted already, please delete.

    Abstract

    Link to full study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365380/
     
    Louie41, Chezboo, Helen and 17 others like this.
  2. arewenearlythereyet

    arewenearlythereyet Senior Member (Voting Rights)

    Messages:
    2,092
    Just read this. It's interesting but obviously a small pilot that needs reproducing with a larger and possibly more comprehensive cohort (only used 17 women aged 42-68). Clearly needs an overlay in terms of men vs women, and severity for future studies. These were the things I picked out:

    1. Interesting that it confirms some other work in terms of disrupted metabolic pathways.
    2. Adds weight to the argument that we could and should have a metabolic profile as a future biomarker (identifies 35-74 possible metabolic markers)
    3. Puts a focus on liver function as an area for further study and an explanation for some of the symptoms.
    4. Puts tenuous links to the neurological aspects in terms of phospholipid metabolism
    5. Highlights that perhaps taurine and lipid supplementation may be possible avenues for treatment?
    6. Falls short of coming up with a unifying theory for disease onset and progression.
     
    Louie41, Cohen, Joh and 16 others like this.
  3. Alvin

    Alvin Senior Member (Voting Rights)

    Messages:
    3,309
    Very interesting.
    I tried reading it but flamed out so thanks for the synopsis
     
    Louie41, Andy, Nellie and 2 others like this.
  4. Londinium

    Londinium Senior Member (Voting Rights)

    Messages:
    267
    Am I right in thinking this is the Hanson study published last year and now becoming open access 12 months later?
     
    Louie41, Joh, Dolphin and 3 others like this.
  5. arewenearlythereyet

    arewenearlythereyet Senior Member (Voting Rights)

    Messages:
    2,092
    Quite possibly ...I enjoyed reading it agin if so :D
     
    Louie41, Joh, Andy and 2 others like this.
  6. Forbin

    Forbin Senior Member (Voting Rights)

    Messages:
    1,427
    This sounds like it might be along the same lines as Nancy Klimas' work on altered homeostasis.
     
  7. Helen

    Helen Senior Member (Voting Rights)

    Messages:
    357
    Last edited: Feb 3, 2018
    Louie41, MeSci, Valentijn and 4 others like this.

Share This Page