Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review. Tomas and Newton (2018)

Jenny TipsforME · Apr 19, 2018

Has anyone got access to the full paper?

Chronic fatigue syndrome (CFS), commonly known as myalgic encephalomyelitis (ME), is a debilitating disease of unknown etiology. CFS/ME is a heterogeneous disease associated with a myriad of symptoms but with severe, prolonged fatigue as the core symptom associated with the disease. There are currently no known biomarkers for the disease, largely due to the lack of knowledge surrounding the eitopathogenesis of CFS/ME.

Numerous studies have been conducted in an attempt to identify potential biomarkers for the disease. This mini-review offers a brief summary of current research into the identification of metabolic abnormalities in CFS/ME which may represent potential biomarkers for the disease.

The progress of research into key areas including immune dysregulation, mitochondrial dysfunction, 5′-adenosine monophosphate-activated protein kinase activation, skeletal muscle cell acidosis, and metabolomics are presented here.

Studies outlined in this mini-review show many potential causes for the pathogenesis of CFS/ME and identify many potential metabolic biomarkers for the disease from the aforementioned research areas.

The future of CFS/ME research should focus on building on the potential biomarkers for the disease using multi-disciplinary techniques at multiple research sites in order to produce robust data sets. Whether the metabolic changes identified in this mini-review occur as a cause or a consequence of the disease must also be established
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http://www.biochemsoctrans.org/content/early/2018/04/16/BST20170503
Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review
Cara Tomas, Julia Newton
Biochemical Society Transactions Apr 17, 2018, BST20170503; DOI: 10.1042/BST20170503

Paragraphs added to aid ME dyslexia

strategist · Apr 19, 2018

Jenny TipsforME said: ↑

Has anyone got access to the full paper?
Click to expand...

http://sci-hub.hk/http://biochemsoctrans.org/lookup/doi/10.1042/BST20170503

Jenny TipsforME · Apr 19, 2018

@strategist thanks I’d actually tried that before and was asked to pay by bitcoin. It works now

Andy · Apr 19, 2018

Hi Jenny, please could you add the year published and authors to your title. Thanks

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Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review. Tomas and Newton (2018)

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Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review. Tomas and Newton (2018)

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