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Kynurenine pathway is altered in patients with SLE and associated with severe fatigue, 2018, Akesson et al.

Discussion in 'Health News and Research unrelated to ME/CFS' started by Jaybee00, Oct 16, 2020.

  1. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    https://lupus.bmj.com/content/5/1/e000254


     
  2. Trish

    Trish Moderator Staff Member

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    Odd error. Niacin is Vitamin B3, not B12.
     
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  3. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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  4. Creekside

    Creekside Senior Member (Voting Rights)

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    The B12 = niacin error jumped out at me too. :) What was missing from the abstract is that they only measured serum and urine levels of metabolites. Since central fatigue is neurological, and many kynurenines don't cross the BBB easily, I consider their findings to be fairly useless. If they'd measured CSF levels, they might have gotten some interesting results. ME might involved fairly localized alterations in glial activity and kynurenine levels, so even a spinal tap may not reveal ME's secrets. I think some method of brain scanning for kynurenines may be needed.
     
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  5. Andy

    Andy Committee Member & Outreach

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    Full abstract
     
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  6. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    Kynurenine again! It's interesting how there was once a theory of too much serotonin causing fatigue in ME, and now it's an imbalance in the tryptophan/kynurenine pathway (both in ME and SLE).

    It's like the elephant in a dark room. Someone's feeling the trunk and thinks it's a snake. Maybe gradually, we can work out how all the bits fit together.
     
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  7. butter.

    butter. Senior Member (Voting Rights)

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    after 4 years in bed 100% I wish I was the elephant ...
     
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  8. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    I'm not sure how to take that! :rofl:
     
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  9. butter.

    butter. Senior Member (Voting Rights)

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    I did not want to go into the snake thing ...
     
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  10. Kitty

    Kitty Senior Member (Voting Rights)

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    It's interesting they appear to suggest that increased circulating levels of kynurenine could be linked to central fatigue, when the OMF trial is exploring the possibility of supplementing it...the objectives of the two studies may be different, though (I'm way out of my depth!)
     
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