Hi @Squeezy only just spotted your thread. Insomnia is my biggest issue after having no energy. I’m mild/moderate level ME tending more to moderate recently. Although I can get out of the house to do stuff I can relate to a lot of what you’re experiencing. Sorry things are tough I hope you get some relief soon. It seems like when my sleep is worse everything else follows. But also when I have been more active the tired but wired kicks in I’m “ok”once I get to sleep it is getting to sleep that is the main problem. Amitryptiline from my GP really wasn’t helping and I I hated that it made me feel even more sluggish in the morning. Following advice from folks online I’ve very recently started taking melatonin which being in the U.K. is not from my GP. A friend got me some from a pharmacy in the US. I just take 1mg a night and it really is helping me get to sleep a lot earlier 1am ish rather than 4am. It’s an improvement because I can get up earlier if I need to do I would recommend anyone give it a try but I’m not noticing any change in my energy. It’s only been a few weeks but wondering if maybe I’m expecting too much.