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Glutamate and fatigue

Discussion in 'Health News and Research unrelated to ME/CFS' started by Marco, Apr 13, 2018.

  1. Marco

    Marco Senior Member (Voting Rights)

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    I've posted this in the non-ME/CFS related section but that doesn't rule out the possibility of relevance.

    Firstly a mouse model that implicates the glutamate transporter GLT-1 in the mediation of exercise induced fatigue (interesting that extracellular glutamate is increased but lactate is decreased in relevant brain area in the fatigued rats) :

    GLT‐1 mediates exercise‐induced fatigue through modulation of glutamate and lactate in rats

    https://onlinelibrary.wiley.com/doi/full/10.1111/neup.12465

    and a just recruiting study that aims to test the effectiveness of Riluzole (a drug which increases glutamate re-uptake) in treating fatigue in breast cancer patients :

    Effects of Riluzole on CNS Glutamate and Fatigue in Breast Cancer Survivors With High Inflammation

    https://clinicaltrials.gov/ct2/show/NCT02796755

    Might be worth keeping an eye on?
     
  2. Marco

    Marco Senior Member (Voting Rights)

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    Another interesting one :

    Sleep Deprivation Distinctly Alters Glutamate Transporter 1 Apposition and Excitatory Transmission to Orexin and MCH Neurons

    http://www.jneurosci.org/content/38/10/2505

    Now I'm feeling a little sleep deprived myself so I can't quite work out whether GLT1 is solely involved in glutamate reuptake or in the transport of glutamate tramsmission across the synaptic cleft - or whether "Reduced GLT1 apposition was associated with tonic presynaptic inhibition of excitatory transmission to these neurons due to the activation of Group III metabotropic glutamate receptors" is a good thing :confused:

    Anyway the takeaway message is that the glutamate transporter GLT1 plays a key role in modulating the activity or wakefullness promoting orexin or sleep promoting melanin-concentrating hormone neurons in the rat hypothalamus and that this modulating activity depends on whether or not the organism is sleep derpived. Presumably sleep deprivation uprates the excitatory role of GLT1 on sleep inducing MCH neurons?

    ETA

    They probably explained it better than I did (my text breaks added) :

     
    Last edited: Apr 13, 2018

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