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Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages, 2018, Freeman et al

Discussion in 'Health News and Research unrelated to ME/CFS' started by Andy, Apr 21, 2018.

  1. Andy

    Andy Committee Member & Outreach

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    Open access at https://www.researchgate.net/public...ptophan-metabolism_genes_by_human_macrophages
     
  2. Woolie

    Woolie Committee member

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    Interesting. However, the explanation may be way simpler than this.

    If you look carefully at the research suggesting a link between inflammation and depression, you notice that only a subset of people with depression have evidence of inflammation, and only a subset respond to anti-inflammatory interventions. That subset are unusual in other ways too - on self-report measures of depression, they score particularly highly on "physiological" items (I feel tired all the time, I have difficulty concentrating, I have difficulty sleeping). And interventions that involve anti-inflammatory drugs tend to alter responses to these items specifically.

    Also, although there's been some studies showing that placing people on interferon can lead to increased scores on self-report measures of depression, the majority of people on interferon score highly mostly on the physiological items. There is only a subset of people that reach clinical levels of depression and that tends to be those who have previously had a depressive episode.

    My conclusion: inflammation is probably not linked with depression in the way we normally understand it, its probably associated with some other set of problems that look a bit similar, especially on self-report measures.

    Sound familiar?

    We need to sort out what depression is before we can start talking about what causes it. To me, it seems like it is a collection of pretty different conditions with different aetiologies.

    (Edited to explain myself better)
     
    Last edited: Apr 22, 2018
    sea, Indigophoton, Amw66 and 9 others like this.
  3. WillowJ

    WillowJ Senior Member (Voting Rights)

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    Would it be fair to say that depression is a symptom that means a variety of things, some of which are experienced by healthy people, some of which may be secondary to various other conditions, and one or more which is a disease in its own right?
     
    sea likes this.

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