"When will we get a sterilizing Covid vaccine?"

Most likely well before Cochrane take any positive action on their review of exercise for CFS....

Thanks for the laugh, @Andy!

I do hope we get a sterilizing vaccine in my lifetime, in all seriousness. I can't afford to get it again so I am still shielding or whatever we might want to call that now! If anyone has any good or hopeful news, I'd love to hear it!
 
Repeat COVID-19 vaccinations elicit antibodies that neutralize variants, other viruses

https://medicine.wustl.edu/news/rep...odies-that-neutralize-variants-other-viruses/
Washington University School of Medicine in St. Louis said:
Response to updated vaccine is shaped by earlier vaccines yet generates broadly neutralizing antibodies

The COVID-19 pandemic is over, but the virus that caused it is still here, sending thousands of people to the hospital each week and spinning off new variants with depressing regularity. The virus’s exceptional ability to change and evade immune defenses has led the World Health Organization (WHO) to recommend annual updates to COVID-19 vaccines.

But some scientists worry that the remarkable success of the first COVID-19 vaccines may work against updated versions, undermining the utility of an annual vaccination program. A similar problem plagues the annual flu vaccine campaign; immunity elicited by one year’s flu shots can interfere with immune responses in subsequent years, reducing the vaccines’ effectiveness.

A new study by researchers at Washington University School of Medicine in St. Louis helps to address this question. Unlike immunity to influenza virus, prior immunity to SARS-CoV-2, the virus that causes COVID-19, doesn’t inhibit later vaccine responses. Rather, it promotes the development of broadly inhibitory antibodies, the researchers report.

The study, available online in Nature, shows that people who were repeatedly vaccinated for COVID-19 — initially receiving shots aimed at the original variant, followed by boosters and updated vaccines targeting variants — generated antibodies capable of neutralizing a wide range of SARS-CoV-2 variants and even some distantly related coronaviruses. The findings suggest that periodic re-vaccination for COVID-19, far from hindering the body’s ability to recognize and respond to new variants, may instead cause people to gradually build up a stock of broadly neutralizing antibodies that protect them from emerging SARS-CoV-2 variants and some other coronavirus species as well, even ones that have not yet emerged to infect humans.
 
A Dutch study has found that there has been a rise in excess deaths since the pandemic which may have been caused by the vaccines. "Researchers from The Netherlands analysed data from 47 Western countries and discovered there had been more than three million excess deaths since 2020, with the trend continuing despite the rollout of vaccines and containment measures."

https://www.telegraph.co.uk/news/20...s-may-have-helped-fuel-rise-in-excess-deaths/


"Writing in the BMJ Public Health, the authors from Vrije Universiteit, Amsterdam, said: “Although Covid-19 vaccines were provided to guard civilians from suffering morbidity and mortality by the Covid-19 virus, suspected adverse events have been documented as well.


“Both medical professionals and citizens have reported serious injuries and deaths following vaccination to various official databases in the Western World.”


"Researchers said the figure included deaths from Covid-19, but also the “indirect effects of the health strategies to address the virus spread and infection”.

They warned that side effects linked to the Covid vaccine had included ischaemic stroke, acute coronary syndrome and brain haemorrhage, cardiovascular diseases, coagulation, haemorrhages, gastrointestinal events and blood clotting."

"However, more recent data regarding side-effects has not been made available to the public, with countries keeping their own individual databases of harms, which rely on self-reporting by the public and doctors, the experts warned."


Other causes of excess deaths
include delay in reporting symptoms.

"Gordon Wishart, chief medical officer at Check4Cancer, and visiting professor of cancer surgery at Anglia Ruskin University, warned repeatedly that delaying cancer diagnosis would lead to deaths.



“It was predicted early in the lockdown period that limited access to healthcare for non-Covid conditions would lead to delays in the diagnosis and treatment of time-critical conditions such as cancer, cardiac disease, diabetes and dementia and that this would lead to excess deaths from these conditions,” he said.

Speaking about the potential for vaccine harm, Mr Wishart added: “The authors are correct to point out that many vaccine-related serious adverse events may have been unreported, and point to the fact that the simultaneous onset of excess mortality and Covid vaccination in Germany is worthy of further investigation on its own.

“The paper provides more questions than answers but, it is hard to disagree with their conclusion that further analysis is required to understand the underlying causes of excess mortality to better prepare for the future management of pandemic crises”
 
I haven't had any covid vaccine yet but I can't go on self-isolating forever, obviously. Looks like the breaking point for me is coming up in a few months' time, so I'm trying to find out what the best current advice/knowledge is regarding how many shots and how far between them, and how long for it to become fully effective, for a "first-timer".

Are there any recently published facts or scientific studies? Can you please help me find the latest and most reliable facts about this, please?

On the Public Health Agency of Sweden's website it says that "since autumn 2023, primary vaccination with Comirnaty or Nuvaxovid includes only 1 dose for everyone who is not immunocompromised". (Sadly, I no longer see them as a trustworthy source of facts or information though, because of how incredibly badly they have handled things so far throughout the pandemic.)

(Edited to fix spelling mistakes.)
 
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Here are a couple of articles about the combination COVID and flu vaccine from Moderna.

From The Conversation:
Results are looking promising for a combined COVID and flu vaccine. Here’s how it could benefit public health

https://theconversation.com/results...res-how-it-could-benefit-public-health-232278
The Conversation said:
Moderna reported the combined vaccine elicited a higher immune response in both age groups against COVID and three influenza strains, compared to the co-administered shots.

From a safety perspective, the combined vaccine was well tolerated. Adverse reactions were similar across the experimental and control groups. The most common side effects included muscle aches, fatigue and pain at the injection site.

While the trial results are promising, they are yet to be published in a peer-reviewed journal, which means independent experts haven’t yet verified them. And further research may be required to test how the combined vaccine works in younger age groups.


From The Washington Post:
What to know about Moderna’s combined covid-flu vaccine on the horizon

Regular link = https://www.washingtonpost.com/health/2024/06/10/covid-flu-combined-vaccine-moderna/

Gift link = https://wapo.st/3z2XCTr
Washington Post said:
Moderna’s combined coronavirus-influenza shot produced a higher immune response in older adults than separate vaccines for those viruses administered together, according to data the company released Monday.

The promising results from clinical trials, which have yet to be peer reviewed and published in a medical journal, could offer a new option to boost paltry uptake of updated coronavirus vaccines.

Moderna officials say the earliest that the combined vaccine could hit the market is fall 2025, pending regulatory approval.

EDIT: I guess the two quote sections are kind of repetitive ...
 
A Dutch study has found that there has been a rise in excess deaths since the pandemic which may have been caused by the vaccines.

See takedown in https://christinapagel.substack.com/p/guest-post-a-terrible-academic-paper

I’m late to this but I wanted to set out some thoughts on the awful BMJ Public Health excess deaths article. Commentary has focussed on media coverage, linking deaths to vaccines, but I want to discuss the article itself, which should not have been published in its current form.

That is not to let The Telegraph, New York Post and others who misreported this off the hook entirely. Reckless reporting has done considerable harm, going well beyond what was claimed in the paper. More lives will be lost as misinformation fuels vaccine hesitancy.

But as I said, when BMJ publishing company distanced itself from media misreporting, this was always going to happen. It's all very well to say the 'study' doesn't establish a link between excess deaths and vaccines, but it's full of inappropriate insinuation.

The first question is why this article was published at all. It adds nothing to the literature. The excess deaths commentary is a copy/paste from World Mortality Dataset, a labour of love by @ArielKarlinsky and @hippopedoid , who are understandably furious.
 
Here are a couple of articles about the combination COVID and flu vaccine from Moderna.

Using mRNA vaccines for Flu is a step backwards in my opinion. Hopefully the clinical trials of the "universal" stalk-region influenza vaccine are successful and renders it all moot.

The stalk region vaccine also has strong safety advantages (it won't trigger GBS for example) too.

An mRNA influenza vaccine has small but real risks of immune thrombocytopenia...
 
Thanks for posting the Substack link @SNT Gatchaman. It clarifies that

"Anyone trying to suggest that vaccines are the cause, or even part of the cause, for excess deaths needs to explain why the most excess deaths are in the least vaccinated countries and vice versa."

It does also acknowledge that "There have of course been people harmed by side effects of Covid vaccines, and some have sadly died. But the scale is orders of magnitude lower."

It suggests the BMJ article should never have been posted at all.
 
Novavax Submits Application to U.S. FDA for Updated Protein-based 2024-2025 Formula COVID-19 Vaccine
  • Novavax's updated JN.1 COVID-19 vaccine is active against current circulating strains, including KP.2 and KP.3
  • Novavax's JN.1 COVID-19 vaccine would be the only protein-based option available in the U.S.
  • Novavax's filing is aligned with FDA, EMA and WHO global recommendations on vaccine composition
  • Novavax intends to have its vaccine in pre-filled syringes available in the U.S. for immediate release post-authorization and following recommendation by the U.S. CDC
LINK
 
Retraction Watch: 'Expression of concern coming for paper some used to link COVID-19 vaccines to deaths'
The journal BMJ Public Health is placing an expression of concern on a paper it said “gave rise to widespread misreporting and misunderstanding,” namely, “claims that it implies a direct causal link between COVID-19 vaccination and mortality.”

The article, “Excess mortality across countries in the Western World since the COVID-19 pandemic: ‘Our World in Data’ estimates of January 2020 to December 2022,” appeared online June 3, and quickly attracted attention and criticism. The expression of concern is not yet live.

BMJ’s press release concluded:

As part of the investigation the authors will be asked to review and respond to the concerns raised to BMJ about the quality and messaging of the paper. BMJ will then decide what further action is needed.

BMJ Expression of concern:
"The integrity team and editors are investigating issues raised regarding the quality and messaging of this work. The Princess Máxima Centre, which is listed as the affiliation of three of the four authors, is also investigating the scientific quality of this study.1 The integrity team has contacted the institution regarding their investigation.

Readers should also be alerted to misreporting and misunderstanding of the work. It has been claimed that the work implies a direct causal link between COVID-19 vaccination and mortality. This study does not establish any such link. The researchers looked only at trends in excess mortality over time, not its causes. The research does not support the claim that vaccines are a major contributory factor to excess deaths since the start of the pandemic. Vaccines have, in fact, been instrumental in reducing the severe illness and death associated with COVID-19 infection."
 
Finland to start bird flu vaccinations for humans in world first

"The vaccine will be offered to those aged 18 or over who are at increased risk of contracting avian influenza due to their work or other circumstances," the Finnish Institute for Health and Welfare (THL) said in a statement.

The H5N1 strain of bird flu has killed or caused the culling of hundreds of millions of poultry globally in recent years and has increasingly been spreading to mammals, including cows in the United States and, in some cases, also to humans.

LINK
 
Covid-10 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network(GVDN) cohort study of 99 million vaccinated individuals

Abstract
Background
The Global COVID Vaccine Safety (GCoVS) Project, established in 2021 under the multinational Global Vaccine Data Network™ (GVDN®), facilitates comprehensive assessment of vaccine safety. This study aimed to evaluate the risk of adverse events of special interest (AESI) following COVID-19 vaccination from 10 sites across eight countries.

Methods
Using a common protocol, this observational cohort study compared observed with expected rates of 13 selected AESI across neurological, haematological, and cardiac outcomes. Expected rates were obtained by participating sites using pre-COVID-19 vaccination healthcare data stratified by age and sex. Observed rates were reported from the same healthcare datasets since COVID-19 vaccination program rollout. AESI occurring up to 42 days following vaccination with mRNA (BNT162b2 and mRNA-1273) and adenovirus-vector (ChAdOx1) vaccines were included in the primary analysis. Risks were assessed using observed versus expected (OE) ratios with 95 % confidence intervals. Prioritised potential safety signals were those with lower bound of the 95 % confidence interval (LBCI) greater than 1.5.

Results
Participants included 99,068,901 vaccinated individuals. In total, 183,559,462 doses of BNT162b2, 36,178,442 doses of mRNA-1273, and 23,093,399 doses of ChAdOx1 were administered across participating sites in the study period. Risk periods following homologous vaccination schedules contributed 23,168,335 person-years of follow-up. OE ratios with LBCI > 1.5 were observed for Guillain-Barré syndrome (2.49, 95 % CI: 2.15, 2.87) and cerebral venous sinus thrombosis (3.23, 95 % CI: 2.51, 4.09) following the first dose of ChAdOx1 vaccine. Acute disseminated encephalomyelitis showed an OE ratio of 3.78 (95 % CI: 1.52, 7.78) following the first dose of mRNA-1273 vaccine. The OE ratios for myocarditis and pericarditis following BNT162b2, mRNA-1273, and ChAdOx1 were significantly increased with LBCIs > 1.5.

Conclusion
This multi-country analysis confirmed pre-established safety signals for myocarditis, pericarditis, Guillain-Barré syndrome, and cerebral venous sinus thrombosis. Other potential safety signals that require further investigation were identified.

LINK


https://www.sciencedirect.com/science/article/pii/S0264410X24001270?via=ihub#s0090
 
I am not participating at the moment but saw this article today and was troubled by a number of issues. I really can't elucidate them now but wondered if anyone else might be interested in elaborating on this.

It concerns a mother who would not allow her adult handicapped son to be vaccinated. A court has finally agreed with her after hearing evidence that it may harm her son and because we are no longer in the position we were during the pandemic. If we were, he would need to take the vaccine. This troubles me. Am interested in others' views.


https://www.telegraph.co.uk/news/2024/07/13/mother-battle-covid-jab-feared-kill-son/

edit: apologies but it is unlikely I will be back in the immediate future in response but I thought this might be of interest because of the issues it raises.
 
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The Hill: "The medical community must stop gaslighting COVID vaccine victims like me"

'Vaccine adverse effects are real. I know it makes some people uncomfortable to acknowledge..but alongside the benefits of vaccines, there are cases of profound harm'

"We are in desperate need..both abandoned by the communities that champion vaccination and co-opted by those opposed to vaccines. We are caught between accusations of jeopardizing vaccine efforts and assertions that we deserve our suffering. This only exacerbates our trauma.'

"I share my story not as an indictment of vaccines but as a call to action. We have an ethical responsibility to provide urgent support for those, in doing what the government asked of them, experienced life-altering, disabling COVID vaccine adverse effects."
 
Editorial: Mechanisms of Guillain-Barré syndrome and its link with COVID-19 and COVID-19 vaccination

In summary, based on our topic manuscripts, we propose that clinicians should be aware of GBS as a potential adverse reaction of COVID-19 vaccinations, although the causal relationship between COVID-19 vaccines and GBS occurrence still needs to be confirmed in large-scale research. Specifically, robust post-vaccination surveillance is warranted, which requires both accurate clinical diagnosis and national reporting mechanisms.

LINK
 
Long-term risk of autoimmune diseases after mRNA-based SARS-CoV2 vaccination in Korean. nationwide, population-based cohort study

Abstract
The long-term association between mRNA-based coronavirus disease 2019 (COVID-19) vaccination and the development of autoimmune connective tissue diseases (AI-CTDs) remains unclear.

In this nationwide, population-based cohort study involving 9,258,803 individuals, we aim to determine whether the incidence of AI-CTDs is associated with mRNA vaccination. The study spans over 1 year of observation and further analyses the risk of AI-CTDs by stratifying demographics and vaccination profiles and treating booster vaccination as time-varying covariate.

We report that the risk of developing most AI-CTDs did not increase following mRNA vaccination, except for systemic lupus erythematosus with a 1.16-fold risk in vaccinated individuals relative to controls. Comparable results were reported in the stratified analyses for age, sex, mRNA vaccine type, and prior history of non-mRNA vaccination.

However, a booster vaccination was associated with an increased risk of some AI-CTDs including alopecia areata, psoriasis, and rheumatoid arthritis. Overall, we conclude that mRNA-based vaccinations are not associated with an increased risk of most AI-CTDs, although further research is needed regarding its potential association with certain conditions.

LINK
 
Cohort study of cardiovascular safety of different COVID-19 vaccination doses among 46 millions adults in England, 2024, Samamtha Ip, et al

Abstract
The first dose of COVID-19 vaccines led to an overall reduction in cardiovascular events, and in rare cases, cardiovascular complications. There is less information about the effect of second and booster doses on cardiovascular diseases.

Using longitudinal health records from 45.7 million adults in England between December 2020 and January 2022, our study compared the incidence of thrombotic and cardiovascular complications up to 26 weeks after first, second and booster doses of brands and combinations of COVID-19 vaccines used during the UK vaccination program with the incidence before or without the corresponding vaccination.

The incidence of common arterial thrombotic events (mainly acute myocardial infarction and ischaemic stroke) was generally lower after each vaccine dose, brand and combination. Similarly, the incidence of common venous thrombotic events, (mainly pulmonary embolism and lower limb deep venous thrombosis) was lower after vaccination. There was a higher incidence of previously reported rare harms after vaccination: vaccine-induced thrombotic thrombocytopenia after first ChAdOx1 vaccination, and myocarditis and pericarditis after first, second and transiently after booster mRNA vaccination (BNT-162b2 and mRNA-1273).

These findings support the wide uptake of future COVID-19 vaccination programs.

LINK
 
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