Circadian rhythm abnormalities and autonomic dysfunction in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, 2018, Cambras et al

Discussion in 'ME/CFS research' started by Andy, Jun 8, 2018.

  1. Andy

    Andy Committee Member

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    Open access at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198106
     
  2. Hutan

    Hutan Moderator Staff Member

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    These seem like well-meaning researchers.

    Can someone invite them to a conference so that they can update their knowledge on GET? And/or send them some information about the PACE trial?
     
  3. Andy

    Andy Committee Member

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    Actually their evidence for their statement isn't the PACE trial. Their reference is "Patient education to encourage graded exercise in chronic fatigue syndrome. 2-year follow-up of randomised controlled trial.", https://www.ncbi.nlm.nih.gov/pubmed/14754826, this response to the study, https://www.bmj.com/content/322/7301/1545, seems to indicate many of the usual problems with it.
     
  4. Trish

    Trish Moderator Staff Member

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    Strange to use as evidence an obscure trial from 15 or more years ago.
     
  5. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    Maybe they know PACE will no longer fly?
     
  6. Hutan

    Hutan Moderator Staff Member

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    I suggested sending information about the PACE trial simply because it is a large trial that proves that GET doesn't 'markedly improve symptoms and activities of daily living' in people with ME/CFS.
     
  7. Trish

    Trish Moderator Staff Member

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    A discussion of thyroid issues on this thread has been moved to a more relevant thread here at the poster's request.
     
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  8. Little Bluestem

    Little Bluestem Senior Member (Voting Rights)

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    Well most of this is over my head, so I calculated the above. That is over 10 thousand (10,920) data points per person! :)
     
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