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Chronic fatigue syndrome and complement activation, 2009, Geller, Giclas

Discussion in 'BioMedical ME/CFS Research' started by Hutan, Dec 8, 2020.

  1. Hutan

    Hutan Moderator Staff Member

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    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028106/
    Chronic fatigue syndrome and complement activation
    Robert Dennis Geller; Patricia C Giclas

    Abstract

     
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  2. Hutan

    Hutan Moderator Staff Member

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    Screen Shot 2020-12-09 at 1.00.17 PM.png


     
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  3. Hutan

    Hutan Moderator Staff Member

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    There has been a recent report of elevated complement product levels in Covid-19:
    Maybe that's not so remarkable, as it sounds as though complement activation fragments are markers for ongoing immune reactions.
     
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  4. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    I'm not convinced this finding is generalisable to all CFS or ME patients, it may simply suggest that there are a range of underlying conditions in people with CFS diagnoses. The authors do not discuss it, but I wonder if the patient was suffering from some form of vasculitis.

    There does seem to be a strong association with SLE:
    https://pubmed.ncbi.nlm.nih.gov/9777539/
    https://academic.oup.com/rheumatology/article/44/10/1227/1788289


    Further reading: https://en.wikipedia.org/wiki/Complement_membrane_attack_complex
     
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  5. wastwater

    wastwater Senior Member (Voting Rights)

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    I’m pinning my hopes on immune Factor I inherited immunodeficiency being the root of my condition it is connected to the eye but is mentioned in other conditions like Autism schizophrenia Parkinson MS and Alzheimer’s
    Maybe anti C5 will stop the complement activation that EBV started
     
    Last edited: Feb 25, 2021

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