Charting the circulating proteome in ME/CFS using cross-system profiling to uncover mechanistic insights, 2026, Hoel, Fluge, Mella+

I have been doing more digging and speculating…

So MCTS1 seems to sometimes work in concert with E2F1.

E2F1 is in the area of this peak on LocusZoom for DecodeME which is below the significance threshold but there seems like there could be something going on in this region (you may need to change the filtering and resize the view to see it as there is a lot going on in this area)

We don’t know if there are genetic differences around MCTS1 yet (as above it’s on the X chromosome which we don’t have results for yet) but this study did highlight higher levels of the protein. And transcription factors like E2F1 interact with lots of things so this may not mean anything. However maybe something to dig into a bit more.
 
hotblack said:
So MCTS1 seems to sometimes work in concert with E2F1.
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Reminds me of Plato's cave.

Our appreciation of the real world is merely seeing fleeting shadows on a wall MCTS1, E2F1...
But that doesn't stop physicists ending up making predictions verifiable to 1 in 10^18.

Somewhere in all this is a causal reality. I think we might find it but don't ask me where at the moment.
 
Jonathan Edwards said:
Somewhere in all this is a causal reality. I think we might find it but don't ask me where at the moment.
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Indeed. My general approach is like someone flailing around on a beach picking up pebbles and holding them up to passers-by and saying, in a hopeful tone, ‘is this interesting?’

I think there are lots of interesting pebbles :) If they tell us anything., who knows. Maybe one day they will.
 
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hotblack said:
I was going to ask those more knowledgeable and experienced in this field (like @DMissa ) what the chances are of someone else looking at ME/CFS proteomics would be of reproducing this.
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Can only speak to what we know other people are doing. I have circulating proteomics on 100 people being done as a small part of one of my studies but it is using olink, not somascan
 
What I do not understand is why on Table 6C there are two entries for the same entity, more specifically the entries "ACRP30" and "Adiponectin". They are the same entity :

https://en.wikipedia.org/wiki/Adiponectin

Interestingly, adiponectin is also related to efferocytosis:

Study in mice :

https://academic.oup.com/jimmunol/a...lement_1/63.1/8001131?redirectedFrom=fulltext

Failure to efficiently clear apoptotic cells (efferocytosis) is associated with autoimmunity. Complement component C1q is required for efferocytosis, and deficiency in C1q leads to development of autoimmunity. We recently identified a novel molecular mechanism for C1q-dependent efferocytosis in mouse macrophages. We found that C1q elicited the expression and function of Mer tyrosine kinase and the Mer ligand, Ga6: a receptor-ligand pair that mediates efferocytosis. To define the signal transduction pathway downstream of C1q, pathway analysis was performed using the transcriptome from C1q-treated macrophages. This analysis revealed that the adiponectin signaling pathway was significantly upregulated with C1q. Adiponectin is a well characterized adipokine with critical roles in glucose and fatty acid metabolism, and it is structurally homologous to C1q. Similar to C1q, adiponectin triggered expression of Mer that correlated with enhanced engulfment of apoptotic cells, and a soluble Mer-Fc fusion protein inhibited adiponectin-dependent efferocytosis.
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More on adiponectin :

https://academic.oup.com/jmcb/article/8/2/120/2459556
 
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