sex differences

Sex Differences in Long COVID Prevalence Over One year After the Acute Phase, and Related Risk Factors. The GINA-COVID Cohort Study Background This 1-year cohort study aimed to track long COVID prevalence, identify associated risk factors, and assess its association with hospitalization...

Why does FND mainly affect women? A consideration of gender imbalance in neuropsychiatric disease [Line breaks added] Background Functional neurological disorder (FND) is a common and disabling neuropsychiatric condition in which women comprise approximately 75% of cases. This paper...

A cellular basis for heightened gut sensitivity in females Visceral pain disorders, such as irritable bowel syndrome, exhibit a marked female prevalence. Enhanced signaling between enterochromaffin (EC) cells in the gut epithelium and mucosal sensory nerve fibers likely contributes to this sex...

Long-term sex differences in symptoms and immune profile in long COVID BACKGROUND Long COVID (LC) is a post-infectious condition affecting millions worldwide, characterized by persistent multisystem symptoms. Females are disproportionately affected, reporting higher symptom burden...

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00522-1 Highlights • Female long COVID (LC) patients show heightened immune activation and inflammation • Disrupted sex hormone levels differ between male and female LC patients • Neuroinflammatory gene signatures may explain...

Sex-specific Axonal Conduction Velocity Development Drives Differential Changes in Frontal, Parietal, and Insular Cortices in Autism Spectrum Disorder Neither the neurological underpinnings of autism spectrum disorder (ASD) nor their contribution to sex differences are well understood. In...

Sex-related cardiometabolic differences in ME/CFS patients Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, debilitating, and multisystem disease that affects more females than males. Core symptoms include persistent fatigue, post-exertional malaise (PEM), unrefreshing...

Mechanisms of sex differences in acute and long COVID sequelae in mice While males are more likely to suffer severe outcomes during acute COVID-19, a greater proportion of females develop post-acute sequalae of COVID-19 (PASC) despite similar rates of infection. To identify mechanisms of PASC...

Circulating Levels of SMPDL3B Define Metabolic Endophenotypes and Subclinical Kidney Alterations in Myalgic Encephalomyelitis Myalgic Encephalomyelitis (ME) is a complex, multisystem disorder with poorly understood pathophysiological mechanisms. SMPDL3B, a membrane-associated protein expressed...

Global and Sex-Stratified Genome-Wide Association Study of Long COVID Based on Patient-Driven Symptom Recall We aimed to explore the global and sex-specific genetic variants associated with long COVID, as defined by patient-driven symptom recall. A 1-year cohort study of 2411 COVID-19 patients...

Choroid plexus alterations in autism spectrum disorder: A PET-MRI study The choroid plexus (CP), primarily known as the production site of cerebrospinal fluid (CSF), constitutes one of the sites of the blood-CSF barrier and plays a unique role in inflammation propagation, serving as a key...

Mitochondrial function is impaired in long COVID patients BACKGROUND The Long COVID syndrome is a major global health problem, affecting approximately 10–20% of individuals infected with SARS-CoV-2 virus with many remaining symptomatic beyond one year. Fatigue, reduced exercise tolerance and...

Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome Anne E. Gardella, Daniel Eweis-LaBolle, Conor J. Loy, Emma D. Belcher, Joan S. Lenz, Carl J. Franconi, Sally Y. Scofield, Andrew Grimson, Maureen R. Hanson, Iwijn De...

Sex differences in inflammation and markers of gut integrity in long COVID Endothelial damage represents an essential pathogenic mechanism of respiratory and multiorgan dysfunction as seen in the post-acute phase of COVID-19. Biological differences between male and female sex, inflammation...

The Critical Role of the Bile Acid Receptor TGR5 in Energy Homeostasis: Insights into Physiology and Therapeutic Potential Zangerolamo, Lucas; Carvalho, Marina; Barbosa, Helena C. L. Over the past decades, bile acids have been recognized as important signaling molecules with significant roles...

Now published, see post #70. Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights August Hoel; Fredrik Hoel; Sissel Elisabeth Furesund Dyrstad; Henrique Chapola; Ingrid Gurvin Rekeland; Kristin Risa; Kine Alme; Kari Sorland; Karl Albert Brokstad...

Abstract: Evidence bearing on possible mechanisms for the clinical syndrome of ME/CFS is reviewed. The evidence is used to argue for a hypothesis that centres on a form of persistent, inappropriate, ‘neuroimmune hypervigilance’ mediated primarily by T lymphocyte-macrophage interaction but...

Now published, see next post. -------------------------------------------- Abstract: Background. Long COVID involves persistent symptoms after COVID-19 recovery, affecting multiple organ systems for months or years. Risk factors include female sex, prior chronic conditions, severe SARS-CoV-2...

Why are women more fatigued than men? The roles of stress, sleep, and repetitive negative thinking Shima Golmohamadi, Bronwyn M. Graham [Line breaks added] Abstract Fatigue, a state of prolonged tiredness that cannot be alleviated through rest, is twice as likely to affect women than men. To...

Biological sex-dependent differences in postural orthostatic tachycardia syndrome POTS Seeley, Marie-Claire; Wilson, Gemma; Ong, Eric; Langdon, Amy; Chieng, Jonathan; Bailey, Danielle; Comacchio, Kristina; Page, Amanda; Lau, Dennis; Gallagher, Celine AIMS This prospective, cross-sectional study...