hif-1

  1. SNT Gatchaman

    Wuhan strain of SARS-CoV-2 triggers activation of immune evasion machinery similar to the one operated by cancer cells, 2025, Abooali et al.

    Wuhan strain of SARS-CoV-2 triggers activation of immune evasion machinery similar to the one operated by cancer cells Abooali, Maryam ; Yasinska, Inna M. ; Thapa, Gauri ; Lei, Xi ; da Costa, Kelly A. S. ; Schlichtner, Stephanie ; Berger, Steffen M. ; Fasler-Kan, Elizaveta ; Temperton, Nigel J...
  2. SNT Gatchaman

    Preprint Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights, 2025, Hoel, Fluge, Mella+

    Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights August Hoel; Fredrik Hoel; Sissel Elisabeth Furesund Dyrstad; Henrique Chapola; Ingrid Gurvin Rekeland; Kristin Risa; Kine Alme; Kari Sorland; Karl Albert Brokstad; Hans-Peter Marti; Olav Mella; Oystein...
    • SNT Gatchaman
    • Thread
    • bone marrow capillaries coagulation complement endothelium ephrin fgf21 fluge gdf15 hif-1 histone hypoxia leptin mcts1 mella myeloperoxidase myoglobin neutrophils pxdn sex differences
    • Replies: 67
    • Forum: ME/CFS research
  3. SNT Gatchaman

    Follow-up assessment of the microvascular function in patients with long COVID, 2025, Romanowska-Kocejko et al.

    Follow-up assessment of the microvascular function in patients with long COVID Romanowska-Kocejko; Braczko; Jędrzejewska; Żarczyńska-Buchowiecka; Kocejko; Kutryb-Zając; Hellmann Long COVID is a complex pathophysiological condition. However, accumulating data suggests that COVID-19 is a systemic...
  4. SNT Gatchaman

    Preprint Inhibition of HIF-2α Pathway as a Potential Therapeutic Strategy for Endothelial Dysfunction in Post-COVID Syndrome, 2024, Ribeiro et al.

    Inhibition of HIF-2α Pathway as a Potential Therapeutic Strategy for Endothelial Dysfunction in Post-COVID Syndrome Andrea Ribeiro; Timon Kuchler; Maciej Lech; Javier Carbajo-Lozoya; Kristina Adorjan; Hans Christian Stubbe; Martina Seifert; Anna Wöhnle; Veronika Kesseler; Johanna Negele; Uwe...
    • SNT Gatchaman
    • Thread
    • endothelial dysfunction hif-1 hif-2 nitric oxide reactive oxygen species spike protein vegf
    • Replies: 5
    • Forum: Long Covid research
  5. Mij

    Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following C-19 infection: genome-wide DNA study

    Epigenetic patterns, accelerated biological aging, and enhanced epigenetic: drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study, 2024, Calzari Luciano, Dragani Davide Fernando et al Abstract Background The epigenetic status of patients 6-month...
    • Mij
    • Thread
    • apoptosis endothelin epigenetics glutamate glutamine hif-1 insulin t cells vegf
    • Replies: 0
    • Forum: Long Covid research
  6. SNT Gatchaman

    Review SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19, 2024, Guarnieri et al.

    SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19 Guarnieri; Haltom; Albrecht; Lie; Olali; Widjaja; Ranshing; Angelin; Murdock; Wallace To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic...
    • SNT Gatchaman
    • Thread
    • atf6 cgas-sting epigenetics fgf21 gdf15 glycolysis hif-1 histone innate immune system integrated stress response interferon metabolic reprogramming metabolism mitochondria oxidative phosphorylation pentose phospate pathway perk tlr-9 upr
    • Replies: 2
    • Forum: Long Covid research
  7. SNT Gatchaman

    Preprint Redefining the role of Hypoxia-inducible factors HIFs in oxygen homeostasis, 2024, Arias et al.

    Redefining the role of Hypoxia-inducible factors HIFs in oxygen homeostasis Clemente Fernández Arias; Franciso J Acosta; Federica Bertocchini; Cristina Fernández-Arias Hypoxia-inducible factors (HIFs) are key regulators of intracellular oxygen homeostasis. The marked increase in HIFs activity...
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    • Thread
    • acetyl co a glycolysis hif-1 hypoxia hypoxic stress lactate metabolix oxidative phosphorylation oxidative stress pyruvate reverse electron transport warburg effect
    • Replies: 0
    • Forum: Other health news and research
  8. SNT Gatchaman

    Preprint BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III, 2024, Chen et al

    BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III Brandon Chen; Theophilus M Lynn-Nguyen; Pankaj Jadhav; Benjamin S Halligan; Nicholas J Rossiter; Rachel M Guerra; Sergei Koshkin; Imhoi Koo; Pietro Morlacchi...
    • SNT Gatchaman
    • Thread
    • brd4 complex 3 endoplasmic reticulum epigenetics hif-1 hypoxia integrated stress response jak inhibitors jak-stat mitochondria mitochondrial dynamics perk
    • Replies: 0
    • Forum: Other health news and research
  9. SNT Gatchaman

    Divergent mechanisms regulate TLR4 expression on PBMCs following workload-matched exercise in normoxic and hypoxic environments, 2023, et al.

    Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments Jeremy B. Ducharme ; Zachary J. McKenna ; Jonathan W. Specht ; Zachary J. Fennel ; Quint N. Berkemeier ; Michael R. Deyhle Exercise...
  10. SNT Gatchaman

    Hypothesis pH sensing at the intersection of tissue homeostasis and inflammation, 2023, Stephanie Hajjar; Xu Zhou

    pH sensing at the intersection of tissue homeostasis and inflammation Stephanie Hajjar; Xu Zhou pH is tightly maintained at cellular, tissue, and systemic levels, and altered pH – particularly in the acidic range – is associated with infection, injury, solid tumors, and physiological and...
  11. SNT Gatchaman

    The Role of the Hypoxia-Related Unfolded Protein Response UPR in the Tumor Microenvironment, 2022, Bartoszewska et al.

    The Role of the Hypoxia-Related Unfolded Protein Response UPR in the Tumor Microenvironment Bartoszewska, Sylwia; Collawn, James F.; Bartoszewski, Rafal Despite our understanding of the unfolded protein response (UPR) pathways, the crosstalk between the UPR and the complex signaling networks...
  12. SNT Gatchaman

    Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts, 2023, Guarnieri et al.

    Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts Joseph W. Guarnieri; Joseph M. Dybas; Hossein Fazelinia; Man S. Kim; Justin Frere; Yuanchao Zhang; Yentli Soto Albrecht; Deborah G. Murdock; Alessia Angelin; Larry N. Singh; Scott L. Weiss; Sonja M...
    • SNT Gatchaman
    • Thread
    • covid fgf21 gdf15 glycolysis glyolysis hif-1 integrated stress response long covid mavs metabolism micro-rna mitochondria oxphos
    • Replies: 14
    • Forum: Long Covid research
  13. Mij

    Environmental and behavioral regulation of HIF-mitochondria crosstalk, 2023, Johannes Burtscher et al

    Highlights Hypoxia inducible factors – mitochondria crosstalk underlies adaptations to hypoxia. Controlled induction of hypoxia responses yields potent health benefits. Environmental and behavioral conditions modulate adaptations to hypoxia. Understanding the determinants of adaptation...
  14. SNT Gatchaman

    Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function, 2023, Iosef et al

    Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function Iosef, Cristiana; Knauer, Michael J.; Nicholson, Michael; Van Nynatten, Logan R.; Cepinskas, Gediminas; Draghici, Sorin; Han, Victor K. M.; Fraser, Douglas D. Aims...
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    • Thread
    • ang-1 hif-1 long covid neutrophil extracellular traps neutrophils nf-κb nk cells tnf vascular vegf
    • Replies: 3
    • Forum: Long Covid research
  15. SNT Gatchaman

    Hypoxia activates the unfolded protein response signaling network: An adaptive mechanism for endometriosis, 2022, Zhou et al.

    Hypoxia activates the unfolded protein response signaling network: An adaptive mechanism for endometriosis Zhou, Yong; Jin, Yang; Wang, Yuan; Wu, Ruijin Endometriosis (EMS) is a chronic gynecological disease that affects women of childbearing age. However, the exact cause remains unclear. The...
  16. SNT Gatchaman

    Recapitulation of pathophysiological features of AD [Alzheimer’s disease] in SARS-CoV-2 infected subjects, 2022/3, Griggs et al

    Preprint See post 5 for published version Molecular and cellular similarities in the brain of SARS-CoV-2 and Alzheimer’s disease individuals Elizabeth Griggs, Kyle Trageser, Sean Naughton, Eun-Jeong Yang, Brian Mathew, Grace Van Hyfte, Linh Hellmers, Nathalie Jette, Molly Estill, Li Shen, Tracy...
  17. SNT Gatchaman

    Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis, 2022, Allen et al

    Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis Allen CNS, Arjona SP, Santerre M, Sawaya BE Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral infections. Metabolic reprogramming provides the cell with energy and biomass for...
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