Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis, 2022, Allen et al

Discussion in 'Other health news and research' started by SNT Gatchaman, Sep 27, 2022.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis
    Allen CNS, Arjona SP, Santerre M, Sawaya BE

    Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral infections. Metabolic reprogramming provides the cell with energy and biomass for large-scale biosynthesis. Based on studies of the cellular changes that contribute to metabolic reprogramming, seven main hallmarks can be identified: (1) increased glycolysis and lactic acid, (2) increased glutaminolysis, (3) increased pentose phosphate pathway, (4) mitochondrial changes, (5) increased lipid metabolism, (6) changes in amino acid metabolism, and (7) changes in other biosynthetic and bioenergetic pathways.

    Viruses depend on metabolic reprogramming to increase biomass to fuel viral genome replication and production of new virions. Viruses take advantage of the non-metabolic effects of metabolic reprogramming, creating an anti-apoptotic environment and evading the immune system. Other non-metabolic effects can negatively affect cellular function. Understanding the role metabolic reprogramming plays in viral pathogenesis may provide better therapeutic targets for antivirals.

    Link | PDF (Viruses)
     
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  2. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Good review paper, which gives background to current investigations into EBV and other viral latency/reactivation, itaconate shunt among others. Will probably require a few read-throughs and a bit of note-taking I'm finding...
     
    alktipping, Mij, Mithriel and 3 others like this.
  3. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Hard to select a few quotes without reproducing the whole paper (which is open-access, so I've been liberal). Some reformatting for legibility —

    *That penultimate sentence is a little confusing and I wonder if it should read more as: "Typically, the cell utilizes mitochondrial oxidative phosphorylation (OXPHOS) when oxygen is available, and only resort to upregulating glycolysis in a hypoxic environment."

     
    alktipping, RedFox, ukxmrv and 3 others like this.

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