Preprint Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights, 2025, Hoel, Fluge, Mella+

Discussion in 'ME/CFS research' started by SNT Gatchaman, May 31, 2025 at 11:38 PM.

  1. forestglip

    forestglip Senior Member (Voting Rights)

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    R^2 of .019
    upload_2025-6-2_8-12-58.png
     
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  2. Chestnut tree

    Chestnut tree Senior Member (Voting Rights)

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    Hi Butter,

    Interesting that you were tested for that. Was that as part of a study or something available to the public?
     
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  3. Chestnut tree

    Chestnut tree Senior Member (Voting Rights)

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  4. ME/CFS Skeptic

    ME/CFS Skeptic Senior Member (Voting Rights)

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    I try to follow ME/CFS research as closely as I can and sometimes write blogs about them. For example, at the end of the year I write an overview of the most interesting studies of the year, which helps to keep track of the most important ones.
    https://mecfsskeptic.com/2024-looking-back-on-a-year-of-me-cfs-research/

    I also notice that I tend to ignore the less quality studies more and more. Many papers just aren't worth the time and effort.
     
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  5. Hutan

    Hutan Moderator Staff Member

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    I find PXDN very interesting too.

    Here's a link to a post I made about earlier findings:
    Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology, 2022, Hejbøl et al
     
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  6. Sean

    Sean Moderator Staff Member

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    Was told once by a senior researcher in materials science that when he gets a paper to read he goes straight to the methodology section, and doesn't read the full paper until he knows it is worth reading. Said it saved him a lot of time.
     
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  7. forestglip

    forestglip Senior Member (Voting Rights)

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    HLA-C has the 39th highest fold change out of the 7326 aptamers they tested (logFC = 0.35). Not significant though (p=.19, q=.45).
    seq.21797.4-HLA-C_boxplots.png
    Here are all the ones they tested that mentioned HLA:
    Edit: Mistyped the q-value.
     
    Last edited: Jun 3, 2025 at 8:41 PM
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