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Preprint Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights, 2025, Hoel, Fluge, Mella+

Discussion in 'ME/CFS research' started by SNT Gatchaman, May 31, 2025 at 11:38 PM.

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  1. forestglip

    forestglip Senior Member (Voting Rights)

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    2,463
    R^2 of .019
    upload_2025-6-2_8-12-58.png
     
    forestglip, Jun 2, 2025 at 1:14 PM
    #61
    hotblack, Sean, Murph and 1 other person like this.
  2. Chestnut tree

    Chestnut tree Senior Member (Voting Rights)

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    488
    Hi Butter,

    Interesting that you were tested for that. Was that as part of a study or something available to the public?
     
    Chestnut tree, Jun 2, 2025 at 6:34 PM
    #62
    MeSci, Deanne NZ and Kitty like this.
  3. Chestnut tree

    Chestnut tree Senior Member (Voting Rights)

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    Chestnut tree, Jun 2, 2025 at 6:43 PM
    #63
    hotblack, Turtle, Deanne NZ and 2 others like this.
  4. ME/CFS Skeptic

    ME/CFS Skeptic Senior Member (Voting Rights)

    Messages:
    4,407
    Location:
    Belgium
    I try to follow ME/CFS research as closely as I can and sometimes write blogs about them. For example, at the end of the year I write an overview of the most interesting studies of the year, which helps to keep track of the most important ones.
    https://mecfsskeptic.com/2024-looking-back-on-a-year-of-me-cfs-research/

    I also notice that I tend to ignore the less quality studies more and more. Many papers just aren't worth the time and effort.
     
    ME/CFS Skeptic, Jun 2, 2025 at 7:42 PM
    #64
    Michelle, Lilas, MeSci and 14 others like this.
  5. Hutan

    Hutan Moderator Staff Member

    Messages:
    32,765
    Location:
    Aotearoa New Zealand
    I find PXDN very interesting too.

    Here's a link to a post I made about earlier findings:
    Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology, 2022, Hejbøl et al
     
    Hutan, Jun 3, 2025 at 6:41 AM
    #65
    MeSci, forestglip and hotblack like this.
  6. Sean

    Sean Moderator Staff Member

    Messages:
    9,089
    Location:
    Australia
    Was told once by a senior researcher in materials science that when he gets a paper to read he goes straight to the methodology section, and doesn't read the full paper until he knows it is worth reading. Said it saved him a lot of time.
     
    Sean, Jun 3, 2025 at 6:42 AM
    #66
    Michelle, MeSci, Utsikt and 6 others like this.
  7. forestglip

    forestglip Senior Member (Voting Rights)

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    2,463
    HLA-C has the 39th highest fold change out of the 7326 aptamers they tested (logFC = 0.35). Not significant though (p=.19, q=.45).
    seq.21797.4-HLA-C_boxplots.png
    Here are all the ones they tested that mentioned HLA:
    Edit: Mistyped the q-value.
     
    Last edited: Jun 3, 2025 at 8:41 PM
    forestglip, Jun 3, 2025 at 8:18 PM
    #67
    MeSci, Hutan, hotblack and 1 other person like this.
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