Castori M, Celletti C, Camerota F, Grammatico P. Chronic fatigue syndrome is commonly diagnosed in patients with Ehlers-Danlos syndrome hypermobility type/joint hypermobility syndrome. Clin Exp Rheumatol. 2011;29(3):597-598. https://www.clinexprheumatol.org/article.asp?a=4635 No abstract, this is a letter to the editor of the journal. Although the authors used the Fukuda criteria, they reported the prevalence of each symptom individually. They also conducted labs & a clinical record review for each patient. The study included 46 people with both EDS hypermobility type (EDS-HT) and joint hypermobility syndrome (JHS). 80.6% (37) had post-exertional malaise, 82.6% (38) had disabling fatigue for >6 months, and overall 82.6% (38) met the Fukuda criteria. Not a perfect match for ME/CFS criteria due to PEM, but it might give a rough impression of the prevalence of CFS in EDS-HT/JHS. Unfortunately, no information is given about the control group (n = 95). Per the table of CFS symptom prevalence in both groups, it clearly includes non-healthy subjects: 43% have unrefreshing sleep, 37% have impaired memory/concentration, etc. Though it is sex-matched and arguably age-matched (ranges: 8-58 for patients with EDS-HT/JHS vs 28-45 for controls). A plausible explanation could be that the controls were just recruited from the physical rehab and/or genetics department(s) the authors worked at. The authors conclude that joint hypermobility, EDS-HT and JHS should be screened for in patients with CFS. Relevant parts (spacing mine): Note: the criteria for EDS-HT and JHS predate the stricter 2017 New York criteria for hypermobile EDS (hEDS). If my understanding is correct, some of these patients would meet the 2017 criteria, while those who don't would now be diagnosed with hypermobility spectrum disorder (HSD). Is this correct @Jonathan Edwards?