https://davidfmarks.com/2021/03/08/me-cfs-as-a-breakdown-in-homeostasis/ Here I present a new theory of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disabling and complex illness affecting tens of millions of people worldwide. The Centers for Disease Control and Prevention (CDC) defines ME/CFS as follows: People with ME/CFS are often not able to do their usual activities. At times, ME/CFS may confine them to bed. People with ME/CFS have overwhelming fatigue that is not improved by rest. ME/CFS may get worse after any activity, whether it’s physical or mental. This symptom is known as post-exertional malaise (PEM). Other symptoms can include problems with sleep, thinking and concentrating, pain, and dizziness. There is no agreed scientific explanation of the disorder, no treatment and no cure. The most popular theory has been that the condition is psychosomatic. In my view, this theory is completely wrong. Here I present a new theory suggesting that ME/CFS is a multi-system disorder disorder in which the homeostasis of the body is broken. Homeostasis is a fundamental physiological principle that ensures equilibrium, stability and safety of the organism in a continuously changing and potentially life-threatening environment.