Australia: National Health and Medical Research Council (NHMRC): Development of ME/CFS guidelines

The NHMRC ME/CFS Clinical Guideline Development Committee recently held its second meeting. This session was a training workshop to help committee members learn about the GRADE approach, a method used to assess the quality of research evidence. NHMRC uses this approach when developing all clinical guidelines. [Summary copied from Emerge Facebook]



The meeting focused on principles of trustworthy guideline development and the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach for assessing the certainty of evidence.

Key highlights​

  • Members explored the foundations of trustworthy guideline development, including systematic review processes, assessing the certainty of evidence and the importance of transparent and structured guideline development approaches.
  • Members considered various international standards and tools for development and assessment of trustworthy guidelines, including the AGREE II tool, the GRADE approach and NHMRC Standards for Guidelines.
  • Members noted NHMRC’s role in guideline development, including governance structures and legislated responsibilities.
  • A key focus was the application of GRADE domains to assess the certainty of evidence in systematic reviews. Members also discussed approaches for rating the importance of outcomes to inform guideline recommendations.

Next steps​

The next meeting of the ME/CFS GDC is anticipated for early December 2025 and will focus on topic prioritisation and key focus areas for the evidence evaluations.
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The NHMRC's approach to GRADE can be seen here:
 
Art Vandelay said:
The NHMRC ME/CFS Clinical Guideline Development Committee recently held its second meeting. This session was a training workshop to help committee members learn about the GRADE approach, a method used to assess the quality of research evidence. NHMRC uses this approach when developing all clinical guidelines. [Summary copied from Emerge Facebook]




The NHMRC's approach to GRADE can be seen here:
Click to expand...

ME/CFS Guideline Development Committee Updates – Emerge Australia

emerge.org.au emerge.org.au

Newest Updates on the ME/CFS GDC​

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Published: 28 October 2025​

Second meeting of the NHMRC ME/CFS Clinical Guideline Development Committee

The NHMRC ME/CFS Clinical Guideline Development Committee recently held its second meeting. This session was a training workshop to help committee members learn about the GRADE approach, a method used to assess the quality of research evidence. NHMRC uses this approach when developing all clinical guidelines.

GRADE (Grading of Recommendations, Assessment, Development and Evaluation) is recognised around the world as best practice for assessing the research evidence used to develop clinical guidelines.

Using the GRADE approach will help make sure that the new ME/CFS clinical guidelines:

– Are transparent and trustworthy, with all evidence assessments clearly explained
– Weigh up both strength of the evidence and possible benefits and risk from treatments
– Take into account the values, preferences and experiences of the ME/CFS community

Read the NHMRC meeting summary

Learn more about GRADE
 
Dolphin said:
Using the GRADE approach will help make sure that the new ME/CFS clinical guidelines:

– Are transparent and trustworthy, with all evidence assessments clearly explained
– Weigh up both strength of the evidence and possible benefits and risk from treatments
– Take into account the values, preferences and experiences of the ME/CFS community
Click to expand...

Sadly, I doubt it will ensure any of those.
 
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