Article: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back! 2021, Ariza

Kitty said:
I don't think we can, at least in many cases. A lot of common viruses cause a fairly characteristic range of symptoms, but unless a patient is worryingly ill and needs investigations, 'I'm pretty sure it's a virus' often as much as the doctor can say.

There are even two viruses that cause glandular fever symptoms, so unless you're tested – which is unusual, as diagnosis is often straightforward enough that no tests are needed – you couldn't be sure whether it was caused by EBV or CMV.
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EBV testing here is just positive or negative. They don't do serology to know which virus caused it.
 
Amw66 said:
EBV testing here is just positive or negative. They don't do serology to know which virus caused it.
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Really? Hm, mine was quite detailed, they looked at five different values, two of which showed 1) fresh EBV infection, 2) past CMV infection. I had no idea this is not the same elsewhere.
 
Wyva said:
Really? Hm, mine was quite detailed, they looked at five different values, two of which showed 1) fresh EBV infection, 2) past CMV infection. I had no idea this is not the same elsewhere.
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Perhaps different in paediatrics ( my daughter was 15 ) .

Just states positive, when I queried the paediatrician she advised that they don't do serology

Given we were at the start of a potential chronic illness and the different impacts EBV and CMV have longterm, I found that weird, but put it down to cost in a socially provided system .
 
John Mac said:
News item on their research

Ohio State researchers isolate biomarker to test for chronic fatigue syndrome

My bolding
https://medicine.osu.edu/news/biomarker-for-chronic-fatigue-syndrome
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From OSU Article said:
“These are very exciting times in our labs, as we currently have NIH funding to validate the dUTPase array ELISA in 4,000 clinical serum from ME/CFS patient cohorts of different severities,” says. Dr. Ariza. “Because it is a noninvasive method, if validated, it could be easily implemented in clinical settings for standard testing.”
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Good to see this :)
 
FMMM1 said:
Yea I immediately thought of Bhupesh Prusty's work. I'm not suggesting that you assume that mitochondrial fragmentation is in fact a biomarker for ME. Bhupesh has been looking for a biomarker for mitochondrial fragmentation --- tome this paper is looking at the same problem from a different angle.
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Bhupesh Prusty has an HHV6 research test for the small non coding RNA's such as U14. Ariza and Williams are now looking at HHV6 in addition to EBV and I'm hoping they will be able to incorporate some tests for HHV6 in their work.

By the way, from reading the tweet I'm assuming Bhupesh Prusty has a collaboration with them, but I could be wrong and that may not necessarily be the case.
 
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