Amino acids as a substitute for impaired ATP production

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salin

Established Member
According to the study by Fluge/Mella

Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome - PMC

Myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) is a debilitating disease of unknown etiology, with hallmark symptoms including postexertional malaise and poor recovery. Metabolic dysfunction is a plausible contributing factor. We ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

and as discussed here
alicec

Thread 'Amino acids and energy production'

I wasn’t sure where to put this. It is general background information about metabolism, but since it is directly relevant to energy production in PWME and hence fatigue, I put it here.

Recently I needed to refresh my memory about how some amino acids are broken down for energy.

I thought I would make a summary of this since several recent studies have shown that defects in other energy production pathways mean that PWME may increasingly rely on amino acids as an energy source - see for example the Fluge and Mella and Armstrong studies.

So for people who like to know how...
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it is possible that normal energy production is disturbed in ME/CFS.

As an alternative method of ATP production, I have therefore been taking amino acids directly as a supplement for almost 9 months.
In my experience, this helps me get through the day much better.

I also overcame my orthostatic intolerance during this time – but of course, I don't know if there is a direct connection.

Almost all of my tested amino acid levels were/are in the lower range, and some are still deficient despite supplementation.

Therefore, I take those that are low/deficient in me twice a day, as well as those listed in Fluge/Mellas' study.

Have you also had experience with amino acid supplements? (positive/negative)
 
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