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  1. Hutan
    Thread

    Mitochondria as target to inhibit proliferation and induce apoptosis of cancer cells: the effects of doxycycline and gemcitabine, 2020, Dijk et al

    https://www.nature.com/articles/s41598-020-61381-9#Fig1 Doxycycline has anti-tumour effects in a range of tumour systems. The aims of this study...
    Thread by: Hutan, Aug 24, 2023, 5 replies, in forum: Other health news and research
  2. Andy
    Thread

    Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) 2012 Booth et al

    Abstract The objectives of this study are to test the hypothesis that the fatigue and accompanying symptoms of Chronic Myalgic...
    Thread by: Andy, Jul 30, 2023, 5 replies, in forum: ME/CFS research
  3. Mij
    Thread

    High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast, 2022, Masak Takaine et al

    Abstract Adenosine triphosphate (ATP) at millimolar levels has recently been implicated in the solubilization of cellular proteins. However, the...
    Thread by: Mij, May 18, 2022, 0 replies, in forum: Other health news and research
  4. darrellpf
    Thread

    Reneo Pharmaceuticals Announces Notice of Allowance for Patent Application on REN001

    "Reneo is a clinical stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic...
    Thread by: darrellpf, Dec 16, 2021, 0 replies, in forum: Other health news and research
  5. Mij
    Thread

    An evolutionary perspective on the Crabtree effect

    The capability to ferment sugars into ethanol is a key metabolic trait of yeasts. Crabtree-positive yeasts use fermentation even in the presence...
    Thread by: Mij, Nov 24, 2021, 0 replies, in forum: Other health news and research
  6. Andy
    Thread

    Efficient extra-mitochondrial aerobic ATP synthesis in neuronal membrane systems, 2021, Ravera et al

    Abstract The nervous system displays high energy consumption, apparently not fulfilled by mitochondria, which are underrepresented therein. The...
    Thread by: Andy, Jul 1, 2021, 0 replies, in forum: Other health news and research
  7. Kalliope
    Thread

    biomolecules: Bioenergetic and Proteomic Profiling of Immune Cells in ME/CFS Patients: An Exploratory Study - Fernandez-Guerra et al - 2021

    biomolecules: Bioenergetic and Proteomic Profiling of Immune Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients: An Exploratory...
    Thread by: Kalliope, Jun 29, 2021, 9 replies, in forum: ME/CFS research
  8. Andy
    Thread

    Hypoxanthine Induces Muscular ATP Depletion and Fatigue via UCP2, 2021, Yin et al

    Hypoxanthine (Hx), an intermediate metabolite of the purine metabolism pathway which is dramatically increased in blood and skeletal muscle during...
    Thread by: Andy, Mar 23, 2021, 0 replies, in forum: Other health news and research
  9. Sly Saint
    Thread

    Role of ATP in Extracellular Vesicle Biogenesis and Dynamics, 2021, Lombardi et al

    Mini Review ARTICLE [IMG]Marta Lombardi1, [IMG]Martina Gabrielli1, [IMG]Elena Adinolfi2 and [IMG]Claudia Verderio1* 1CNR Institute of...
    Thread by: Sly Saint, Mar 15, 2021, 0 replies, in forum: Other health news and research
  10. Mij
    Thread

    Increased demand for NAD+ relative to ATP drives aerobic glycolysis Alba Luengo et al, 2020

    Highlights • PDH activation suppresses cell proliferation by reducing the NAD+/NADH ratio • Insufficient ATP demand slows mitochondria NAD+...
    Thread by: Mij, Feb 19, 2021, 0 replies, in forum: Other health news and research
  11. Hoopoe
    Thread

    Increased demand for NAD+ relative to ATP drives aerobic glycolysis, 2020, Luengo et al

    I wonder whether this anything to do with ME/CFS. These data argue that cells engage in aerobic glycolysis when the NAD+ demand for oxidation...
    Thread by: Hoopoe, Dec 31, 2020, 3 replies, in forum: Other health news and research
  12. Jaybee00
    Thread

    Elevated Energy Production in Chronic Fatigue Syndrome Patients, Lawson et al. 2016

    https://pubmed.ncbi.nlm.nih.gov/27747291/ http://www.jnsci.org/files/article/2016/e221.pdf Abstract Chronic Fatigue Syndrome (CFS) is a...
    Thread by: Jaybee00, Sep 8, 2020, 1 replies, in forum: ME/CFS research
  13. Jaybee00
    Thread

    Mitochondrial protein interaction landscape of SS-31, 2020, Chavez et al.

    https://www.pnas.org/content/early/2020/06/16/2002250117 popular article here...
    Thread by: Jaybee00, Jun 19, 2020, 1 replies, in forum: Other health news and research
  14. Dolphin
    Thread

    Metabolic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome not due to anti-mitochondrial antibodies, 2020, Nilsson et al

    http://www.diva-portal.org/smash/record.jsf?pid=diva2%3A1415500&dswid=9881 Nilsson, Isabell Palmer, Jeremy Apostolou, Eirini Linköping...
    Thread by: Dolphin, Mar 21, 2020, 5 replies, in forum: ME/CFS research
  15. John Mac
    Thread

    An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients Missailidis et al. 2019

    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic condition characterized by fatigue that is unaided by rest and by...
    Thread by: John Mac, Sep 4, 2019, 67 replies, in forum: ME/CFS research
  16. Marky
    Thread

    Suggested Pathology of Systemic Exertion Intolerance Disease [...] (2019) Bohne

    Title:Suggested Pathology of Systemic Exertion Intolerance Disease: Impairment ofthe E3 Subunit or Crossover of Swinging Arms of the E2 Subunit of...
    Thread by: Marky, Jun 15, 2019, 26 replies, in forum: ME/CFS research
  17. Andy
    Thread

    Exogenously Applied Muscle Metabolites Synergistically Evoke Sensations of Muscle Fatigue and Pain in Human Subjects, 2014, Light et al

    As this came up in a different thread, I thought it would be worth creating a separate thread for it. Abstract The perception of fatigue is...
    Thread by: Andy, Jan 4, 2019, 0 replies, in forum: ME/CFS research
  18. Andy
    Thread

    Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells, 2015, Chinopoulos et al

    I think this might be of interest to us but really it's so technical I'm out of my depth. What caught my attention was recalling that this...
    Thread by: Andy, Apr 2, 2018, 0 replies, in forum: Other health news and research
  19. Cheshire
    Thread

    Cellular bioenergetics is impaired in patients with CFS (2017) Tomas, Strassheim, Newton et al

    Cara Tomas, Audrey Brown, Victoria Strassheim, Joanna Elson, Julia Newton, Philip Manning Plos One 2017 oct Abstract Chronic fatigue syndrome...
    Thread by: Cheshire, Oct 24, 2017, 47 replies, in forum: ME/CFS research
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