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Altered Erythrocyte Biophysical Properties in Chronic Fatigue Syndrome, 2019, Saha, Davis, et al

Discussion in 'ME/CFS research' started by Andy, Feb 21, 2019.

  1. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    Conference Abstract : RED BLOOD CELL BIOMECHANICS IN CHRONIC FATIGUE SYNDROME
    Amit K. Saha et al

    Summer Biomechanics, Bioengineering and Biotransport Conference
    June 25 -28, Seven Springs, PA, USA
    https://www.researchgate.net/public...Cell_Biomechanics_in_Chronic_Fatigue_Syndrome

     
    Aroa, Hutan, sb4 and 5 others like this.
  2. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    They were presenting the same study at the conference as the one of this thread but with additional data on membrane fluidity, reactive oxygen species, and surface charge, of RBCs, and modelling.

    They are also working on a follow up study with a new cohort of patients that measures more parameters
    https://twitter.com/user/status/1150168583709822978
     
    andypants, Joh, Aroa and 6 others like this.
  3. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    This looked to be significant new information
    upload_2019-7-17_14-6-17.png
     
    andypants, Aroa, Hutan and 4 others like this.
  4. Midnattsol

    Midnattsol Moderator Staff Member

    Messages:
    3,574
    Fits well with that metabolomics dataset that showed reduce vitamin E metabolites or something? Vitamin E is important for protecting cell membranen from oxidative damage. Not to say that ME patients have a diet deficient in vitamin E, but we might have increased need for that and some other stuff I'm too tired to write about to protect our cella against whatever is going wrong.
     
    andypants, sb4, Amw66 and 1 other person like this.
  5. sb4

    sb4 Senior Member (Voting Rights)

    Messages:
    144
    Earlier in this thread it was said that capillary diameters cannot be increased so best to focus on improving RBC deformability. I am just wandering, could increased vasodialation as seen in POTS be some kind of attempt to increase capillary diameter or is this just not possible?
     
  6. Trish

    Trish Moderator Staff Member

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    51,860
    Location:
    UK
    Interesting question. Here's an answer I found:

    Capillaries are the smallest blood vessels. They are unique in that:

    1. They don't have any muscular component like arterioles or venules do.
    2. They are lined by a single layer of endothelium (cells lining blood vessels are called endothelial cells) overlying the basement membrane.
    Due to these reasons the capillaries are very permeable facilitating nutrient and gas exchange.

    The capillaries don't expand as they do not have muscular or elastic components. However exposure to heat do increase the circulation. This is due to the following facts:

    1. Exposure to heat dilates the pre-capillary arterioles - this would inevitably cause improved capillary circulation in capillaries that are already open.
    2. Increase in pre-capillary flow opens up collapsed capillaries. In the human body roughly only one-fourth of the capillaries are open during rest1. As the pre-capillary arterioles dilate, the collapsed capillaries open up thus further improving circulation.
    To improve capillary perfusion:

    • Temporary improvement can be achieved by activity (exercise), exposure to warmth, emotions (flushing is due to vasodilation), even exposure to cold causes vasodilation after the initial vasoconstriction
    • Permanent improvement of capillary circulation can be achieved by increasing capillary density. Capillary density refers to the number of capillaries present in 1 cm2 area. Capillary density can be increased by consistent anaerobic (isometric and to some extent isotonic) exercise.
    References:
    1: Boron and Boupaep text book of medical physiology, 2nd Edition, p.467

    https://biology.stackexchange.com/questions/28258/blood-circulation-how-to-expand-blood-capillaries
     
    voner, Aroa, ladycatlover and 3 others like this.
  7. Hutan

    Hutan Moderator Staff Member

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    Location:
    Aotearoa New Zealand
    from the related thread:

     
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  8. Midnattsol

    Midnattsol Moderator Staff Member

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    3,574
    Sounds plausible to me. Increased NO could be positive due to the vasodilation effects, but NO is also an inhibitor of energy production..
     
  9. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    948
    sb4, Amw66 and Daisymay like this.

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