tryptophan

  1. Andy

    AhR/IL-22 pathway as new target for the treatment of post-infectious irritable bowel syndrome symptoms, 2022, Maëva et al

    ABSTRACT Alterations in brain/gut/microbiota axis are linked to Irritable Bowel Syndrome (IBS) physiopathology. Upon gastrointestinal infection, chronic abdominal pain and anxio-depressive comorbidities may persist despite pathogen clearance leading to Post-Infectious IBS (PI-IBS). This study...
  2. Sly Saint

    Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2021, Simonato et al

    Abstract Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) differ for triggers, mode of start, associated symptoms, evolution, and biochemical traits. Therefore, serious attempts are underway to partition them into subgroups useful for a personalized medicine approach to...
    • Sly Saint
    • Thread
    • 2021 cytokines fatty acids me/cfs metabolites paper simonato tryptophan
    • Replies: 5
    • Forum: ME/CFS research
  3. Mij

    Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections, 2019, Sühs et al

    Abstract Background The tryptophan–kynurenine–nicotinamide adenine dinucleotide (oxidized; NAD+) pathway is closely associated with regulation of immune cells toward less inflammatory phenotypes and may exert neuroprotective effects. Investigating its regulation in central nervous system (CNS)...
  4. Andy

    Inhibition of Tryptophan Catabolism Is Associated With Neuroprotection During Zika Virus Infection, 2021, Martins Marim et al

    Zika virus (ZIKV) is an arbovirus belonging to Flaviviridae family that emerged as a global health threat due to its association with microcephaly and other severe neurological complications, including Guillain-Barré Syndrome (GBS) and Congenital Zika Syndrome (CZS). ZIKV disease has been linked...
  5. A

    The IDO2 tryptophan trap hypothesis

    There are some issues and concerns around the IDO2 tryptophan trap hypothesis about ME. These are my current thought directions, and should not be considered scientific fact. Please comment, add links, agree or disagree, or move this post to somewhere better if you are a moderator. Concerns...
    • alex3619
    • Thread
    • aetiology discussion thread hypothesis ido ido2 me/cfs tryptophan tryptophan trap
    • Replies: 7
    • Forum: ME/CFS research news
  6. J

    MEAction 2021 MECFS researchers video with R Davis,Prusty

  7. Andy

    Inflammation control & improvement of cognitive function in COVID-19: is there a role for kynurenine 3-monooxygenase inhibition?, Collier et al, 2021

    Full title: Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition? Open access, https://www.sciencedirect.com/science/article/pii/S1359644621000751
  8. leokitten

    The NAD+ Long COVID Theory

    The Team of Doctors and Biohackers Who Seem to Be Successfully Treating “Long Covid” There’s actually quite a number of research papers on this.
  9. Andy

    Searching for Peripheral Biomarkers in Neurodegenerative Diseases: The Tryptophan-Kynurenine Metabolic Pathway, 2020, Torok et al

    Open access, https://www.mdpi.com/1422-0067/21/24/9338/htm
  10. Andy

    Liquid chromatography-mass spectrometry .. reveals increased levels of tryptophan indole metabolites in .. metabolic syndrome, 2020, Wrobel et al

    Full title: Liquid chromatography-mass spectrometry untargeted metabolomics reveals increased levels of tryptophan indole metabolites in urine of metabolic syndrome patients Paywall, https://journals.sagepub.com/doi/10.1177/1469066720964632 Sci hub, https://sci-hub.se/10.1177/1469066720964632
  11. Andy

    An Insight into the Roles of Dietary Tryptophan and its Metabolites in Intestinal Inflammation and Inflammatory Bowel Disease, 2020, Qi et al

    Paywall, https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202000461 Sci hub, https://sci-hub.se/10.1002/mnfr.202000461
  12. J

    Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit, 2020, Yamashita

    https://journals.sagepub.com/doi/full/10.1177/1178646920936279
  13. Andy

    Hepatocyte-intrinsic type I interferon signaling reprograms metabolism [..] compensatory mechanism of the tryptophan-kynurenine pathway, 2020, Lercher

    Full title: Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis Open access, https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008973
  14. Andy

    Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor, 2020, Scott et al

    Paywall, https://www.pnas.org/content/early/2020/07/24/2000047117 Sci hub, https://sci-hub.tw/10.1073/pnas.2000047117
  15. Andy

    Increased Expression of (IDO) in Vogt-Koyanagi-Harada (VKH) Disease May Lead to a Shift of T Cell Responses Toward a Treg Population, 2020,Zhang et al

    Full title: Increased Expression of Indoleamine 2,3-Dioxygenase (IDO) in Vogt-Koyanagi-Harada (VKH) Disease May Lead to a Shift of T Cell Responses Toward a Treg Population Paywall, https://link.springer.com/article/10.1007/s10753-020-01252-7 Sci hub, https://sci-hub.tw/10.1007/s10753-020-01252-7
  16. Andy

    The Kynurenine connection: how exercise shifts muscle tryptophan metabolism & affects energy homeostasis, the immune system & the brain, 2020, Martin

    Paywall, https://journals.physiology.org/doi/abs/10.1152/ajpcell.00580.2019 Sci-hub not available at time of posting.
  17. Marky

    L-carnitine, tryptophane and d-ribose

    These are all supplements I have considered during the years.. But ive forgotten a lot about what ive read about them haha.. I know Fluge & Mella experimented with L-Carnitine, but I think some of the patients had side effects if remember correctly.. Has anyone here tried any of these, either...
  18. Andy

    Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder, 2020, Sakurai et al

    Open access, https://www.nature.com/articles/s41598-020-58806-w
  19. John Mac

    The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS 2019 Kashi, Davis, Phair.

    https://www.mdpi.com/2075-4418/9/3/82
    • John Mac
    • Thread
    • 2019 guillemin kashi kynurenine me/cfs metabolic trap paper pathogenesis phair ron davis tryptophan
    • Replies: 49
    • Forum: ME/CFS research
  20. NelliePledge

    Stanford Community Symposium 2018: Phair, Metabolic traps, Tryptophan trap

    This thread has been split from the main Stanford Community Symposium 2018 thread. Interesting presentation on metabolic traps focussing on tryptophan/kyneurenine. Serotonin And a very clear and strong message from Ron Davis that people should not experiment on themselves because he said...
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