An Insight into the Roles of Dietary Tryptophan and its Metabolites in Intestinal Inflammation and Inflammatory Bowel Disease, 2020, Qi et al

[Andy]

Inflammatory bowel disease (IBD) is complex, chronic, and relapsing gastrointestinal inflammatory disorders, which includes mainly two conditions, namely ulcerative colitis (UC) and Crohn's disease (CD). Development of IBD in any individual is closely related to his/her autoimmune regulation, gene‐microbiota interactions and dietary factors. Dietary tryptophan (Trp) is an essential amino acid for intestinal mucosal cells, and it is associated with the intestinal inflammation, epithelial barrier and energy homeostasis of the host. According to the recent studies, Trp and its three major metabolic pathways, namely kynurenine (KYN) pathway, indole pathway and 5‐Hydroxytryptamine (5‐HT) pathway, have vital roles in the regulation of intestinal inflammation by acting directly or indirectly on the pro/anti‐inflammatory cytokines, functions of various immune cells, as well as the intestinal microbial composition and homeostasis. In this review, we summarize recent advances in Trp‐ and its metabolites‐associated intestinal inflammation. We further discuss the complex mechanisms and interrelationships of the three major metabolic pathways of Trp in regulating inflammation, which could elucidate the value of dietary Trp to be used as a nutrient for IBD patients.

Paywall, https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202000461
Sci hub, https://sci-hub.se/10.1002/mnfr.202000461

 

[Creekside]

My ME problems with TRP seem to be in excess conversion to neurotoxic kynurenines in the brain. BCAAs can block, or at least delay and spread out the increase in symptom severity, so I'm pretty sure it's not a digestive system problem. Hopefully there won't be too many people with this neurological sensitivity to TRP and who also have IBD that would be helped by taking TRP.