staines

Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) patients suffer from neurocognitive impairment. In this study, we investigated cortical volumetric and thickness changes in ME/CFS patients and healthy controls (HC). We estimated mean surface-based cortical volume and thickness from...

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious disorder of unknown aetiology. While the pathomechanism of ME/CFS remains elusive, reduced natural killer (NK) cell cytotoxic function is a consistent immunological feature. NK cell effector functions...

Abstract Background The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19) triggers the development of numerous pathologies and infection-linked complications and exacerbates existing pathologies in nearly all body systems. Aside from the primarily targeted...

Characterization of IL-2 Stimulation and TRPM7 Pharmacomodulation in NK Cell Cytotoxicity and Channel Co-Localization with PIP2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multisystemic disorder...

Abstract Chronic fatigue syndrome (CFS) is a heterogenous disorder of multiple disabling symptoms with complex manifestations. Network analysis is a statistical and interrogative methodology to investigate the prevalence of symptoms (nodes) and their inter-dependent (inter-nodal) relationships...

Abstract The transient receptor potential (TRP) superfamily of ion channels is involved in the molecular mechanisms that mediate neuroimmune interactions and activities. Recent advancements in neuroimmunology have identified a role for TRP cation channels in several neuroimmune disorders...

Abstract (1) Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multifaceted illness. The pathomechanism, severity and progression of this illness is still being investigated. Stressors have been implicated in symptom exacerbation for ME/CFS, however, there is...

The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients Natalie Eaton-Fitch, Hélène Cabanas, Stanley du Preez, Donald Staines & Sonya Marshall-Gradisnik Abstract...

Abstract (1) Background—Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multifaceted illness characterized by profound and persistent fatigue unrelieved by rest along with a range of other debilitating symptoms. Experiences of unrefreshing and disturbed sleep are frequently...

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02742-4

The successful applicants for Australia’s $3m ME/CFS Targeted Call for Research (TCR) have been announced. The successful projects: Professor Sonya Marshall-Gradisnik Griffith University Grant: $1.46m Project title: Ion channel dysfunction in the pathophysiology of Myalgic Encephalomyelitis/...

A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02452-3

A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) Teilah Kathryn Huth, Natalie Eaton-Fitch, Donald Staines & Sonya Marshall-Gradisnik...

A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques Rebekah Maksoud , Stanley du Preez, Natalie Eaton-Fitch, Kiran Thapaliya, Leighton Barnden, Hélène Cabanas, Donald Staines, Sonya Marshall-Gradisnik Published...

"Naltrexone restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients" https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/abstract (No full text yet.)

Open access at https://molmed.biomedcentral.com/articles/10.1186/s10020-019-0083-4

Edit: This thread includes several other threads merged with it. Some earlier threads on this team's work: The Courier Mail: Australian scientists prove CFS is real and have discovered a test for it Dec 2017 to Jan 2018 Don Staines and Griffith Aug 2018 Australia - Parliamentarians learn...

Announcement on Facebook from NCNED https://www.facebook.com/permalink.php?story_fbid=1453570698108723&id=301252900007181 Not yet available online from the journal as far as my Google skills could tell me.

Your disease is real: Breakthrough in diagnosis of chronic fatigue syndrome Researchers found chronic fatigue syndrome and the related myalgic encephalomyelitis, or ME, is a calcium ion channel impairment condition. For those who are living with ME/CFS, the announcement proves the disease is...

"Don Staines explained that, given these findings, we could see that “recommendations to exercise patients are wrong” because it only places greater demand for calcium ions in the cells. This also explains why patients who meet the diagnostic criteria defined in the Canadian Consensus Criteria...