scheibenbogen

Introduction: Following the shift of SARS-CoV-2 from pandemic to endemic, post COVID syndrome (PCS) joins the list of already known post-acute infection syndromes (PAIS) and its most severe manifestation, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The exact pathomechanism of...

Abstract: Post-COVID syndrome (PCS) has emerged as a significant health concern with persisting symptoms. A subset of PCS patients develops severe myalgic encephalomyelitis/chronic fatigue syndrome (pcME/CFS). Dysregulated autoantibodies (AABs) have been implicated in PCS, contributing to immune...

Abstract: Background: Epstein-Barr virus (EBV) infection is a known trigger and risk factor for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID syndrome (PCS). In previous studies, we found enhanced IgG reactivity to EBV EBNA4 and EBNA6 arginine-rich sequences in...

ABSTRACT Background Recent studies provide strong evidence for a key role of skeletal muscle pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In a 2021 review article on the pathophysiology of ME/CFS, we postulated that hypoperfusion and ischemia can result in...

Scientific conference led by Prof. Carmen Scheibenbogen on the care, research and therapy of ME/CFS and post-COVID syndrome. The two-day hybrid event is aimed at doctors, medical professionals, researchers and interdisciplinary experts from the fields of medicine and biology.
 The event will...

A new phenotype of patients with post-COVID-19 condition is characterised by a pattern of complex ventilatory dysfunction, neuromuscular disturbance and fatigue symptoms Fridolin Steinbeis; Claudia Kedor; Hans-Jakob Meyer; Charlotte Thibeault; Mirja Mittermaier; Philipp Knape; Katharina Ahrens...

Preprint Link to published paper here ** The Lancet: Efficacy of Repeat Immunoadsorption in Post-COVID ME/CFS Patients with Elevated B2-Adrenergic Receptor Autoantibodies: A Prospective Cohort Study Abstract Background: Since the pandemic, SARS-CoV-2 has become the leading trigger for ME/CFS...

Free: https://journals.lww.com/painrpts/fulltext/2024/08000/antibody_mediated_autoimmunity_in_symptom_based.4.aspx MEETING PROCEEDINGS Antibody-mediated autoimmunity in symptom-based disorders: position statement and proceedings from an international workshop Abstract A 2-day closed workshop...

Practical Recommendations for Exercise Training in Patients with Long COVID with or without Post-exertional Malaise: A Best Practice Proposal Gloeckl, Rainer; Zwick, Ralf H.; Fürlinger, Ulrich; Schneeberger, Tessa; Leitl, Daniela; Jarosch, Inga; Behrends, Uta; Scheibenbogen, Carmen; Koczulla...

Role of the complement system in Long COVID Vadim Farztdinov; Boris Zuehlke; Franziska Sotzny; Fridolin Steinbeis; Martina Seifert; Claudia Kedor; Kirsten Wittke; Pinkus Tober-Lau; Kathrin Textoris-Taube; Daniela Ludwig; Clemens Dierks; Dominik Bierbaum; Leif Erik Sander; Leif Gunnar Hanitsch...

Guideline for the funding of interdisciplinary collaborations for research into the pathomechanisms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Federal Gazette of 01.09.2023 https://www.bmbf.de/bmbf/shareddocs/bekanntmachungen/de/2023/09/2023-09-01-Bekanntmachung-ME-CFS.html...

Scheibenbogen et al Abstract There is increasing evidence for an autoimmune aetiology in post-infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). SARS-CoV-2 has now become the main trigger for ME/CFS. We have already conducted two small proof-of-concept studies of IgG...

eClinicalMedicine Long-term symptom severity and clinical biomarkers in post-COVID-19/chronic fatigue syndrome:results from a prospective observational cohort Legler et al Summary Background Post-COVID-19 syndrome (PCS) is characterised by a wide range of symptoms, primarily fatigue and...

Scheibenbogen et al Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic illness and patients with ME/CFS are often medically underserved in Germany and other countries. One contributing factor is health professionals’ lack of knowledge about epidemiology...

Abstract: Fatigue is the most commonly reported and debilitating extraglandular symptom of primary Sjögren′s syndrome (pSS). Fatigue and exertional intolerance are hallmark symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We aimed to characterize fatigue and further...

Preprint. Now published see post #6 Abstract Background: Infectious mononucleosis, caused by the Epstein-Barr Virus (EBV-IM), has been linked to the development of myalgic encephalomyelitis/chronic fatigue-syndrome (ME/CFS) in children, adolescents, and young adults. Our study presents the...

The sequela of COVID-19 include a broad spectrum of symptoms that fall under the umbrella term post-COVID-19 condition or syndrome (PCS). Immune dysregulation, autoimmunity, endothelial dysfunction, viral persistence, and viral reactivation have been identified as potential mechanisms. However...

There have been quite a lot of improvements in the ME/CFS situation in Germany. There are now investment in research, the IQWiG report, political discussions on ME/CFS etc. I realise these are all still inadequate and that the situation for ME/CFS patients in Germany remains dire. But the pace...

preprint Abstract Introduction Post-COVID-19 syndrome (PCS) is characterized by a wide range of symptoms, predominantly fatigue and exertional intolerance. While disease courses during the first year post infection have been repeatedly described, little is known about long-term health...