sars-cov-2

SARS-CoV-2 Omicron subvariants evolved to promote further escape from MHC-I recognition Miyu Moriyama, Carolina Lucas, Valter Silva Monteiro, Yale SARS-CoV-2 Genomic Surveillance Initiative, Akiko Iwasaki SARS-CoV-2 variants of concern (VOCs) possess mutations that confer resistance to...

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D Madeline J. Lee, Michelle W. Leong, Arjun Rustagi, Aimee Beck, Leiping Zeng, Susan Holmes,4 Lei S. Qi, Catherine A. Blish Natural killer (NK) cells are cytotoxic effector cells that target and...

Potent Antiviral Activity against HSV-1 and SARS-CoV-2 by Antimicrobial Peptoids Diamond G, Molchanova N, Herlan C, Fortkort JA, Lin JS, Figgins E, Bopp N, Ryan LK, Chung D, Adcock RS, Sherman M, Barron AE Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2...

Full title: Association of Initial SARS-CoV-2 Test Positivity With Patient-Reported Well-being 3 Months After a Symptomatic Illness Open access: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799116 Question How do patient-reported physical, mental, and social well-being compare...

Diminished Antiviral Innate Immune Gene Expression in the Placenta Following a Maternal SARS-CoV-2 Infection Coler B, Tsung-Yen WU, Carlson L, Burd N, Munson J, Dacanay M, Cervantes O, Esplin S, Kapur RP, Feltovich H, Adams Waldorf KM Background: Coronavirus disease 2019 (COVID-19) is caused by...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID-19), in part because of its ability to effectively suppress host cell responses1,2,3. In rare cases, viral proteins dampen...

SARS-CoV-2-specicific [sic] humoral immunity in convalescent patients with mild COVID-19 is supported by CD4+ T-cell help and negatively correlated with Alphacoronavirus-specific antibody titer Marcus Odendahl, Iris Endler, Beate Haubold, Roman N. Rodionov, Stefan R. Bornstein, Torsten Tonn...

SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4) Kan Li, Liu Yao, Jin Wang, Hao Song, Yan-hong Zhang, Xue Bai, Kai Zhang, Dong-ming Zhou, Ding Ai, Yi Zhu Letter to Nature: Signal Transduction and Targeted Therapy Link | PDF

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy (Non peer-reviewed) Jae Kyu Ryu, Elif G Sozmen, Karuna Dixit, Mauricio Montano, Yusuke Matsui, Yixin Liu, Ekram Helmy, Thomas J Deerinck, Zhaoqi Yan, Renaud Schuck, Rosa Meza Acevedo, Collin M...

Comparison of Seroconversion in Children and Adults With Mild COVID-19 Zheng Quan Toh, Jeremy Anderson, Nadia Mazarakis, Melanie Neeland, Rachel A. Higgins, Karin Rautenbacher, Kate Dohle, Jill Nguyen, Isabella Overmars, Celeste Donato, Sohinee Sarkar, Vanessa Clifford, Andrew Daley, Suellen...

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 Leo Swadling, et al. Individuals with potential exposure to SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T-cells...

Another fantastic article by Ed Yong, on the abysmal experience of health care workers dealing with gaslighting and denial from their colleagues. Very similar to Royal Free and other outbreaks, just on a much larger scale. It seems that health care workers do not like being treated like they...

UK Study: 1 in 4 people who were infected and tested PCR positive for COVID did NOT go on to develop IgG antibodies. Particularly if they were asymptomatic and elderly. Abstract Understanding the trajectory, duration, and determinants of antibody responses after SARS-CoV-2 infection can...

Abstract Background Activation of the immune system is implicated in the Post-Acute Sequelae after SARS-CoV-2 infection (PASC) but the mechanisms remain unknown. Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (Ang II) resulting in decreased activation of the AT1 receptor and...

(Paragraphs added for legibility) The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of coronavirus disease 2019 (COVID-19). Across the globe, a subset of patients who sustain an acute SARS-CoV-2 infection are developing a wide range of persistent...

Many COVID-19 survivors of all ages experience alarming neurological and physical signs and symptoms post-infection. Dementia-like symptoms, including memory loss and confusion—described as "brain fog"—are lingering burdens for some, while others confront an array of physical symptoms including...

As many others have pointed out, the clusters of symptoms reported by patients post-COVID-19 are not unique or specific to long COVID. Patients with similar assortments of chronic symptoms are commonly encountered in neurology, rheumatology, infectious diseases, and other subspecialty clinics...

Moderator note. This post has been copied and following posts moved from this thread: Possibility of ME or PVFS after Covid-19 Big thanks to @Andy for posting this. I posted similar on Twitter and got very lucky It's amazing and, hopefully, this will lead to serious action by the WHO.

Performed detailed molecular and spatial analysis of the COVID-19 brain immune response Pathognomonic microglial nodules and T cell infiltration are present in COVID-19 brains Altered microglia-T cell interactions correlate with systemic measures of inflammation Vascular leakage is linked with...

Eric Song, Christopher M. Bartley, Ryan D. Chow, Thomas T. Ngo, Ruoyi Jiang, Colin R. Zamecnik, Ravi Dandekar, Rita P. Loudermilk, Yile Dai, Feimei Liu, Sara Sunshine, Jamin Liu, Wesley Wu, Isobel A. Hawes, Bonny D. Alvarenga, Trung Huynh, Lindsay McAlpine, Nur-Taz Rahman, Bertie Geng, Jennifer...