research methodology

How to read a paper involving artificial intelligence (AI) Paul Dijkstra, Trisha Greenhalgh, Yosra Magdi Mekki, Jessica Morley Abstract This paper guides readers through the critical appraisal of a paper that includes the use of artificial intelligence (AI) in clinical settings for healthcare...

https://www.nature.com/articles/s41591-024-03433-5 The updated Declaration of Helsinki empowers ethics committees to require community engagement and equitable partnerships 1964 saw the US Surgeon General report that smoking is a health hazard, the UK abolish the death penalty for murder, and...

Link to paper Abstract NK cell cytotoxicity is a widely used measure to determine the effect of outside intervention on NK cell function. However, the accuracy and reproducibility of this assay can be considered unstable, either because of user's errors or because of the sensitivity of NK...

Correcting the scientific record on abortion and mental health outcomes Julia H Littell; Kathryn M Abel; M Antonia Biggs; Robert W Blum; Diana Greene Foster; Lisa B Haddad; Brenda Major; Trine Munk-Olsen; Chelsea B Polis; Gail Erlick Robinson; Corinne H Rocca; Nancy Felipe Russo; Julia R...

Abstract Objectives: To propose a checklist that can be used to assess trustworthiness of randomized controlled trials (RCTs). Design: A screening tool was developed using the four-stage approach proposed by Moher et al. This included defining the scope, reviewing the evidence base, suggesting...

Authors from the Technological University Dublin (Ireland) & the Eindhoven University of Technology (Netherlands) Received 30 Jan 2023, Accepted 04 Oct 2023, Published online: 29 Nov 2023 Abstract Two factors that decrease the replicability of studies in the scientific literature are...

Compelling evidence from meta-epidemiological studies demonstrates overestimation of effects in randomized trials that fail to optimize randomization and blind patients and outcome assessors [A number of authors are from Gordon Guyatt’s group at McMaster University in Canada] Objective To...

Interesting article about "a wildly popular UW [University of Washington] course taught by Bergstrom and West, 'Calling Bullshit: Data Reasoning in a Digital World,' and a book with a similar name." https://artsci.washington.edu/news/2023-09/hows-your-bs-detector (line breaks added) FYI...

Full title: Time dependent changes in the bioenergetics of peripheral blood mononuclear cells: processing time, collection tubes and cryopreservation effects Objectives: Bioenergetic measurements in peripheral blood mononuclear cells (PBMCs) using high-throughput respirometry is a promising...

Developing, optimising and implementing a blended digital self-management tReatmEnt for FatigUe in multiplE scLerosis (REFUEL-MS) https://fundingawards.nihr.ac.uk/award/NIHR203290 https://www.refuel-ms.com/ Chief Investigator(s): Professor Rona Moss-Morris Co-investigators Start Date...

Posts moved from News from Aotearoa/New Zealand and the Pacific Islands The dietician has asked "how feasible it is to measure people’s experience of fatigue and change in severity of fatigue in response to a nutrition intervention. ...PEM is a feature of ME/CFS and I would like to hear... how...

Recommendations for the development, implementation, and reporting of control interventions in efficacy and mechanistic trials of physical, psychological, and self-management therapies: the CoPPS Statement Control interventions (often called “sham,” “placebo,” or “attention controls”) are...

(Thread created at the request of a member) IQWIG The independent Institute for Quality and Efficiency in Health Care (Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen, IQWiG) examines the benefits and harms of medical interventions for patients...

Patel KV, Amtmann D, Jensen MP, Smith SM, Veasley C, Turk DC. Clinical outcome assessment in clinical trials of chronic pain treatments. Pain Rep. 2021 Jan 21;6(1):e784. doi: 10.1097/PR9.0000000000000784. PMID: 33521482; PMCID: PMC7837993. Abstract Clinical outcome assessments (COAs) measure...

Identifying and managing problematic trials: A research integrity assessment tool for randomized controlled trials in evidence synthesis Stephanie Weibel, Maria Popp, Stefanie Reis, Nicole Skoetz, Paul Garner, Emma Sydenham Abstract Evidence synthesis findings depend on the assumption that...

Ensuring the Voice of the Very Severely Affected Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patient Is Heard in Research—A Research Model 25% ME Group Abstract Most of the research about Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has focused on ambulant patients who...

Quackery is on the rise, and the placebo effect is part of the problem https://edzardernst.com/2022/06/quackery-is-on-the-rise-and-the-placebo-effect-is-part-of-the-problem/ Prof. Fabricio Benedetti is one of the world’s leading experts in the study of placebo effects. I have mentioned his...

Dr Nina Rzechorzek, MRC Clinician Scientist Fellow from the MRC Laboratory for Molecular Biology who led the study, said: “Using the most comprehensive exploration to date of normal human brain temperature, we’ve established ‘HEATWAVE’ – a 4D temperature map of the brain. This map provides an...

Mapping microglia and astrocyte activation in vivo using diffusion MRI Raquel Garcia-Hernandez, Antonio Cerdán Cerdá, Alejandro Trouve Carpena, Mark Drakesmith, Kristin Koller, Derek K Jones, Santiago Canals, Silvia De Santis While glia are increasingly implicated in the pathophysiology of...

American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Felson DT, Anderson JJ, Boers M, Bombardier C, Furst D, Goldsmith C, Katz LM, Lightfoot R Jr, Paulus H, Strand V, et al.Arthritis Rheum. 1995 Jun;38(6):727-35. doi: 10.1002/art.1780380602. Free to...