me/cfs

Registered interventional trials fail to cover patient-prioritised treatments in Post-COVID condition (PCC) Purpose Despite the substantial health and socioeconomic burden of Post-COVID condition (PCC), no disease-modifying therapy has been established, largely because of clinical...

Uncertainty-Driven Healthcare Epistemic Injustice: Evidence from Chronic Fatigue Syndrome Hugh Robertson-Ritchie Abstract In this thesis, I critique inappropriate and unhelpful responses to radical epistemic uncertainties in medicine, which, I argue, significantly contribute to epistemic...

Comprehensive review of myalgic encephalomyelitis/chronic fatigue syndrome Jeyaraman, Madhan; Jeyaraman, Naveen; Ramasubramanian, Swaminathan; Schäfer, Luise; Migliorini, Filippo; Balaji, Sangeetha Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, debilitating...

Epigenome-wide profiling identifies distinct DNA methylation architecture underlying ME/CFS and fibromyalgia symptom burden Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia are overlapping chronic disorders characterized by fatigue, pain, cognitive...

Long COVID, chronic fatigue syndrome, and chronic lyme disease as Post-acute Infection Syndromes (PAIS): a translational synthesis Sewell, Patrick E.; Reddy, Rohan Background Post-acute infection syndromes (PAIS) comprise a heterogeneous group of chronic, multisystem conditions characterized...

Functional enrichment of immune targeted gut microbiota in post-infectious myalgic encephalomyelitis/chronic fatigue syndrome Abstract Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a debilitating condition characterized primarily by profound fatigue and...

A cardiometabolic perspective on post-exertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID Westermeier, Francisco; Pretorius, Etheresia; Untersmayr, Eva; Bertinat, Romina; Sepúlveda, Nuno; Fisman, Enrique Abstract Post-exertional malaise (PEM), the...

The increase of alpha-melanocyte-stimulating hormone in the plasma of chronic fatigue syndrome patients Background Despite extensive research, no reliable biological marker for chronic fatigue syndrome (CFS) has yet been identified. However, hyperactivation of melanotrophs in the pituitary...

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: Preliminary findings Abstract The syndrome of chronic fatigue, feverishness, diffuse pains, and other constitutional complaints, often precipitated by an acute infectious illness and aggravated by...

Transforming biomedical uncertainty: the sociohistorical origins of myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) Cross, Sally Abstract Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are serious and disabling long-term conditions characterised by...

Association between myalgic encephalomyelitis/chronic fatigue syndrome and irritable bowel syndrome: a systematic review and meta-analysis Rajabi, Natalie; Ramdass, Prakash V. A. K. Background Irritable bowel syndrome (IBS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are...

Compound Ciwujia Granules for chronic fatigue syndrome with syndrome of deficiency of both heart and spleen: a multicenter, randomized, double-blind, double-dummy, positive drug-controlled trial Jun Ren, Xiao-Tian Zhang, Chao-Qun Xie, Shou-Jian Wang, Ling-Jun Kong, Jing-Hu Li, Liang-Ji Liu...

Hormonal Responses to Exercise in Chronic Fatigue Syndrome Abstract Chronic fatigue syndrome (CFS) is a debilitating disease characterized by severe, unexplained fatigue and postexertional exacerbation of symptoms. We examined basal endocrine function in a group of CFS patients and a...

Muscle Symptoms Define a Stable Physiological Dysregulation Cluster in ME/CFS: Sex- and Menopause-Related Differences in Symptom Expression Habermann-Horstmeier, Lotte; Horstmeier, Lukas Maximilian Background Muscle-related symptoms are among the most disabling manifestations of myalgic...

High Dimensional Profiling of T cells in ME/CFS Uncovers Sex Specific Dysregulation McNally, Claire; Davis, Mark; Wilhelmy, Julie; Grimson, Andrew; Hanson, Maureen Introduction Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME) is a debilitating and poorly understood chronic disease. ME...

ME/CFS and the thalamus as a precision gate: what reversible thalamocortical connectivity reveals about central gain in post-infectious fatigue Strube, Andreas Abstract Kim and colleagues report a finding that is easy to understate: thalamic hyperconnectivity with sensorimotor and...

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) gene expression signatures for the identification of compounds targeting metabolism Dehlia, Ankush; Alizada, Zahra; Guthridge, Mark Andrew Background Pathological fatigue is a debilitating symptom in a range of chronic illnesses...

Contrasting neuroendocrine responses in depression and chronic fatigue syndrome Abstract Hypothalamic-pituitary-adrenal (HPA) axis and central 5-HT function were compared in chronic fatigue syndrome (CFS), depression and healthy states. 10 patients with CFS and 15 patients with major...

Orthostatic intolerance with small heart and/or disequilibrium in patients with myalgic encephalomyelitis/chronic fatigue syndrome: clinical update and paradigm shift Miwa, Kunihisa Abstract Orthostatic intolerance (OI) is characterized by the inability to maintain an upright posture without...

In the newest study by Wüst and colleagues, they have both a Long Covid and a pre pandemic ME/CFS group. Both groups fulfill CCC, so experience PEM. My question: is there any research into severe Long Covid (e.g. at least 12 months and disabling) that does not also fulfill ME/CFS criteria? I...